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Lenzen Sigurd
Lenzen Sigurd
Professor of Experimental Diabetes Research
Dirección de correo verificada de mh-hannover.de - Página principal
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The mechanisms of alloxan-and streptozotocin-induced diabetes
S Lenzen
Diabetologia 51 (2), 216-226, 2008
34252008
Mechanisms of pancreatic β-cell death in type 1 and type 2 diabetes: many differences, few similarities
M Cnop, N Welsh, JC Jonas, A Jorns, S Lenzen, DL Eizirik
Diabetes 54 (suppl_2), S97-S107, 2005
19402005
Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells
M Tiedge, S Lortz, J Drinkgern, S Lenzen
Diabetes 46 (11), 1733-1742, 1997
15101997
Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues
S Lenzen, J Drinkgern, M Tiedge
Free Radical Biology and Medicine 20 (3), 463-466, 1996
13901996
Oxidative stress: the vulnerable β-cell
S Lenzen
Biochemical Society Transactions 36 (3), 343-347, 2008
6352008
Relative importance of transport and alkylation for pancreatic beta-cell toxicity of streptozotocin
M Elsner, B Guldbakke, M Tiedge, R Munday, S Lenzen
Diabetologia 43, 1528-1533, 2000
5812000
Alloxan: history and mechanism of action
S Lenzen, U Panten
Diabetologia 31, 337-342, 1988
4251988
Concentration-dependent effects of tolbutamide, meglitinide, glipizide, glibenclamide and diazoxide on ATP-regulated K+ currents in pancreatic B-cells
BJ Zünkler, S Lenzen, K Manner, U Panten, G Trube
Naunyn-Schmiedeberg's archives of pharmacology 337, 225-230, 1988
2711988
Complementary action of antioxidant enzymes in the protection of bioengineered insulin-producing RINm5F cells against the toxicity of reactive oxygen species.
M Tiedge, S Lortz, R Munday, S Lenzen
Diabetes 47 (10), 1578-1585, 1998
2621998
Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes.
S Lortz, M Tiedge, T Nachtwey, AE Karlsen, J Nerup, S Lenzen
Diabetes 49 (7), 1123-1130, 2000
2452000
Peroxisome-generated hydrogen peroxide as important mediator of lipotoxicity in insulin-producing cells
M Elsner, W Gehrmann, S Lenzen
Diabetes 60 (1), 200-208, 2011
2372011
Control of insulin secretion by sulfonylureas, meglitinide and diazoxide in relation to their binding to the sulfonylurea receptor in pancreatic islets
U Panten, J Burgfeld, F Goerke, M Rennicke, M Schwanstecher, ...
Biochemical pharmacology 38 (8), 1217-1229, 1989
2101989
A fresh view of glycolysis and glucokinase regulation: history and current status
S Lenzen
Journal of Biological Chemistry 289 (18), 12189-12194, 2014
2092014
Role of metabolically generated reactive oxygen species for lipotoxicity in pancreatic β‐cells
W Gehrmann, M Elsner, S Lenzen
Diabetes, Obesity and Metabolism 12, 149-158, 2010
2042010
Thiol-group reactivity, hydrophilicity and stability of alloxan, its reduction products and its N-methyl derivatives and a comparison with ninhydrin
S Lenzen, R Munday
Biochemical pharmacology 42 (7), 1385-1391, 1991
2021991
Improvement of the mitochondrial antioxidant defense status prevents cytokine-induced nuclear factor-κB activation in insulin-producing cells
AK Azevedo-Martins, S Lortz, S Lenzen, R Curi, DL Eizirik, M Tiedge
Diabetes 52 (1), 93-101, 2003
2012003
Thyroid hormones, gonadal and adrenocortical steroids and the function of the islets of Langerhans
S Lenzen, CJ Bailey
Endocrine Reviews 5 (3), 411-434, 1984
1981984
Importance of the GLUT2 glucose transporter for pancreatic beta cell toxicity of alloxan
M Elsner, M Tiedge, B Guldbakke, R Munday, S Lenzen
Diabetologia 45, 1542-1549, 2002
1852002
Mitochondrial catalase overexpression protects insulin-producing cells against toxicity of reactive oxygen species and proinflammatory cytokines
E Gurgul, S Lortz, M Tiedge, A Jorns, S Lenzen
Diabetes 53 (9), 2271-2280, 2004
1672004
Comparative toxicity of alloxan, N-alkylalloxans and ninhydrin to isolated pancreatic islets in vitro
A Jorns, R Munday, M Tiedge, S Lenzen
Journal of endocrinology 155 (2), 283-294, 1997
1671997
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Artículos 1–20