| Somatic activation of the K-ras oncogene causes early onset lung cancer in mice L Johnson, K Mercer, D Greenbaum, RT Bronson, D Crowley, ... Nature 410 (6832), 1111-1116, 2001 | 1369 | 2001 |
| K-ras is an essential gene in the mouse with partial functional overlap with N-ras L Johnson, D Greenbaum, K Cichowski, K Mercer, E Murphy, E Schmitt, ... Genes & development 11 (19), 2468-2481, 1997 | 750 | 1997 |
| Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis JA Joyce, A Baruch, K Chehade, N Meyer-Morse, E Giraudo, FY Tsai, ... Cancer cell 5 (5), 443-453, 2004 | 747 | 2004 |
| Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools D Greenbaum, KF Medzihradszky, A Burlingame, M Bogyo Chemistry & biology 7 (8), 569-581, 2000 | 721 | 2000 |
| Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities Y Choe, F Leonetti, DC Greenbaum, F Lecaille, M Bogyo, D Bromme, ... Journal of Biological Chemistry 281 (18), 12824-12832, 2006 | 502 | 2006 |
| Chemical approaches for functionally probing the proteome D Greenbaum, A Baruch, L Hayrapetian, Z Darula, A Burlingame, ... Molecular & Cellular Proteomics 1 (1), 60-68, 2002 | 383 | 2002 |
| Synthesis and Structure−Activity Relationships of Parasiticidal Thiosemicarbazone Cysteine Protease Inhibitors against Plasmodium falciparum, Trypanosoma brucei, and … DC Greenbaum, Z Mackey, E Hansell, P Doyle, J Gut, CR Caffrey, ... Journal of medicinal chemistry 47 (12), 3212-3219, 2004 | 359 | 2004 |
| A role for the protease falcipain 1 in host cell invasion by the human malaria parasite DC Greenbaum, A Baruch, M Grainger, Z Bozdech, KF Medzihradszky, ... Science 298 (5600), 2002-2006, 2002 | 358 | 2002 |
| Distinct protein classes including novel merozoite surface antigens in Raft-like membranes of Plasmodium falciparum PR Sanders, PR Gilson, GT Cantin, DC Greenbaum, T Nebl, DJ Carucci, ... Journal of Biological Chemistry 280 (48), 40169-40176, 2005 | 293 | 2005 |
| Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs M Bogyo, S Verhelst, V Bellingard-Dubouchaud, S Toba, D Greenbaum Chemistry & biology 7 (1), 27-38, 2000 | 280 | 2000 |
| Development of α-helical calpain probes by mimicking a natural protein–protein interaction H Jo, N Meinhardt, Y Wu, S Kulkarni, X Hu, KE Low, PL Davies, ... Journal of the American Chemical Society 134 (42), 17704-17713, 2012 | 279 | 2012 |
| Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter S Yasothornsrikul, D Greenbaum, KF Medzihradszky, T Toneff, R Bundey, ... Proceedings of the National Academy of Sciences 100 (16), 9590-9595, 2003 | 249 | 2003 |
| Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages Y Yasuda, Z Li, D Greenbaum, M Bogyo, E Weber, D Brömme Journal of Biological Chemistry 279 (35), 36761-36770, 2004 | 231 | 2004 |
| Small molecule affinity fingerprinting: a tool for enzyme family subclassification, target identification, and inhibitor design DC Greenbaum, WD Arnold, F Lu, L Hayrapetian, A Baruch, J Krumrine, ... Chemistry & biology 9 (10), 1085-1094, 2002 | 211 | 2002 |
| Inhibition of cathepsin B reduces β-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate β-secretase of … V Hook, T Toneff, M Bogyo, D Greenbaum, KF Medzihradszky, J Neveu, ... Biological chemistry 386 (9), 931-940, 2005 | 209 | 2005 |
| Apicomplexan parasites co-opt host calpains to facilitate their escape from infected cells R Chandramohanadas, PH Davis, DP Beiting, MB Harbut, C Darling, ... science 324 (5928), 794-797, 2009 | 201 | 2009 |
| Functional expression and characterization of Schistosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase M Sajid, JH McKerrow, E Hansell, MA Mathieu, KD Lucas, I Hsieh, ... Molecular and biochemical parasitology 131 (1), 65-75, 2003 | 192 | 2003 |
| O-sulfonation of serine and threonine: mass spectrometric detection and characterization of a new posttranslational modification in diverse proteins throughout the eukaryotes KF Medzihradszky, Z Darula, E Perlson, M Fainzilber, RJ Chalkley, H Ball, ... Molecular & Cellular Proteomics 3 (5), 429-440, 2004 | 170 | 2004 |
| The Trypanosoma cruzi Protease Cruzain Mediates Immune Evasion PS Doyle, YM Zhou, I Hsieh, DC Greenbaum, JH McKerrow, JC Engel PLoS pathogens 7 (9), e1002139, 2011 | 163 | 2011 |
| Bestatin-based chemical biology strategy reveals distinct roles for malaria M1-and M17-family aminopeptidases MB Harbut, G Velmourougane, S Dalal, G Reiss, JC Whisstock, O Onder, ... Proceedings of the National Academy of Sciences 108 (34), E526-E534, 2011 | 155 | 2011 |
