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Doron Greenbaum
Doron Greenbaum
Phelix Therapeutics LLC
Verified email at phelixtherapeutics.com - Homepage
Title
Cited by
Cited by
Year
Somatic activation of the K-ras oncogene causes early onset lung cancer in mice
L Johnson, K Mercer, D Greenbaum, RT Bronson, D Crowley, ...
Nature 410 (6832), 1111-1116, 2001
13382001
K-ras is an essential gene in the mouse with partial functional overlap with N-ras
L Johnson, D Greenbaum, K Cichowski, K Mercer, E Murphy, E Schmitt, ...
Genes & development 11 (19), 2468-2481, 1997
7451997
Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis
JA Joyce, A Baruch, K Chehade, N Meyer-Morse, E Giraudo, FY Tsai, ...
Cancer cell 5 (5), 443-453, 2004
7342004
Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools
D Greenbaum, KF Medzihradszky, A Burlingame, M Bogyo
Chemistry & biology 7 (8), 569-581, 2000
7142000
Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities
Y Choe, F Leonetti, DC Greenbaum, F Lecaille, M Bogyo, D Bromme, ...
Journal of Biological Chemistry 281 (18), 12824-12832, 2006
4842006
Chemical approaches for functionally probing the proteome
D Greenbaum, A Baruch, L Hayrapetian, Z Darula, A Burlingame, ...
Molecular & Cellular Proteomics 1 (1), 60-68, 2002
3782002
Synthesis and Structure−Activity Relationships of Parasiticidal Thiosemicarbazone Cysteine Protease Inhibitors against Plasmodium falciparum, Trypanosoma brucei, and …
DC Greenbaum, Z Mackey, E Hansell, P Doyle, J Gut, CR Caffrey, ...
Journal of medicinal chemistry 47 (12), 3212-3219, 2004
3512004
A role for the protease falcipain 1 in host cell invasion by the human malaria parasite
DC Greenbaum, A Baruch, M Grainger, Z Bozdech, KF Medzihradszky, ...
Science 298 (5600), 2002-2006, 2002
3502002
Distinct protein classes including novel merozoite surface antigens in Raft-like membranes of Plasmodium falciparum
PR Sanders, PR Gilson, GT Cantin, DC Greenbaum, T Nebl, DJ Carucci, ...
Journal of Biological Chemistry 280 (48), 40169-40176, 2005
2882005
Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs
M Bogyo, S Verhelst, V Bellingard-Dubouchaud, S Toba, D Greenbaum
Chemistry & biology 7 (1), 27-38, 2000
2782000
Development of α-helical calpain probes by mimicking a natural protein–protein interaction
H Jo, N Meinhardt, Y Wu, S Kulkarni, X Hu, KE Low, PL Davies, ...
Journal of the American Chemical Society 134 (42), 17704-17713, 2012
2672012
Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter
S Yasothornsrikul, D Greenbaum, KF Medzihradszky, T Toneff, R Bundey, ...
Proceedings of the National Academy of Sciences 100 (16), 9590-9595, 2003
2452003
Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages
Y Yasuda, Z Li, D Greenbaum, M Bogyo, E Weber, D Brömme
Journal of Biological Chemistry 279 (35), 36761-36770, 2004
2242004
Small molecule affinity fingerprinting: a tool for enzyme family subclassification, target identification, and inhibitor design
DC Greenbaum, WD Arnold, F Lu, L Hayrapetian, A Baruch, J Krumrine, ...
Chemistry & biology 9 (10), 1085-1094, 2002
2102002
Inhibition of cathepsin B reduces β-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate β-secretase of …
V Hook, T Toneff, M Bogyo, D Greenbaum, KF Medzihradszky, J Neveu, ...
Biological chemistry 386 (9), 931-940, 2005
2062005
Apicomplexan parasites co-opt host calpains to facilitate their escape from infected cells
R Chandramohanadas, PH Davis, DP Beiting, MB Harbut, C Darling, ...
science 324 (5928), 794-797, 2009
1992009
Functional expression and characterization of Schistosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase
M Sajid, JH McKerrow, E Hansell, MA Mathieu, KD Lucas, I Hsieh, ...
Molecular and biochemical parasitology 131 (1), 65-75, 2003
1902003
O-sulfonation of serine and threonine: mass spectrometric detection and characterization of a new posttranslational modification in diverse proteins throughout the eukaryotes
KF Medzihradszky, Z Darula, E Perlson, M Fainzilber, RJ Chalkley, H Ball, ...
Molecular & Cellular Proteomics 3 (5), 429-440, 2004
1672004
The Trypanosoma cruzi Protease Cruzain Mediates Immune Evasion
PS Doyle, YM Zhou, I Hsieh, DC Greenbaum, JH McKerrow, JC Engel
PLoS pathogens 7 (9), e1002139, 2011
1592011
A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei
ZB Mackey, TC O'Brien, DC Greenbaum, RB Blank, JH McKerrow
Journal of Biological Chemistry 279 (46), 48426-48433, 2004
1472004
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