Benjamin T. Walters
Benjamin T. Walters
Genentech Inc.
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Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments
GR Masson, JE Burke, NG Ahn, GS Anand, C Borchers, S Brier, ...
Nature methods 16 (7), 595-602, 2019
Stepwise protein folding at near amino acid resolution by hydrogen exchange and mass spectrometry
W Hu, BT Walters, ZY Kan, L Mayne, LE Rosen, S Marqusee, ...
Proceedings of the National Academy of Sciences 110 (19), 7684-7689, 2013
Minimizing back exchange in the hydrogen exchange-mass spectrometry experiment
BT Walters, A Ricciuti, L Mayne, SW Englander
Journal of the American Society for Mass Spectrometry 23 (12), 2132-2139, 2012
Protein hydrogen exchange at residue resolution by proteolytic fragmentation mass spectrometry analysis
ZY Kan, BT Walters, L Mayne, SW Englander
Proceedings of the National Academy of Sciences 110 (41), 16438-16443, 2013
Many overlapping peptides for protein hydrogen exchange experiments by the fragment separation-mass spectrometry method
L Mayne, ZY Kan, P Sevugan Chetty, A Ricciuti, BT Walters, ...
Journal of the American Society for Mass Spectrometry 22 (11), 2011
Folding of a large protein at high structural resolution
BT Walters, L Mayne, JR Hinshaw, TR Sosnick, SW Englander
Proceedings of the National Academy of Sciences 110 (47), 18898-18903, 2013
An Efficient Organic Solvent Based Extraction Method for the Proteomic Analysis of Arabidopsis Plasma Membranes
SK Mitra, BT Walters, SD Clouse, MB Goshe
Journal of proteome research 8 (6), 2752-2767, 2009
An allosteric anti-tryptase antibody for the treatment of mast cell-mediated severe asthma
HR Maun, JK Jackman, DF Choy, KM Loyet, TL Staton, G Jia, A Dressen, ...
Cell 179 (2), 417-431. e19, 2019
Mutational landscape of antibody variable domains reveals a switch modulating the interdomain conformational dynamics and antigen binding
P Koenig, CV Lee, BT Walters, V Janakiraman, J Stinson, TW Patapoff, ...
Proceedings of the National Academy of Sciences 114 (4), E486-E495, 2017
Interlaboratory comparison of hydrogen–deuterium exchange mass spectrometry measurements of the Fab fragment of NISTmAb
JW Hudgens, ES Gallagher, I Karageorgos, KW Anderson, JJ Filliben, ...
Analytical chemistry 91 (11), 7336-7345, 2019
Solid-state hydrogen–deuterium exchange mass spectrometry: correlation of deuterium uptake and long-term stability of lyophilized monoclonal antibody formulations
BS Moorthy, IE Zarraga, L Kumar, BT Walters, P Goldbach, EM Topp, ...
Molecular pharmaceutics 15 (1), 1-11, 2018
Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation
MJ Holliday, A Witt, A Rodríguez Gama, BT Walters, CP Arthur, ...
Nature Communications 10 (1), 3070, 2019
Conformational destabilization of immunoglobulin G increases the low pH binding affinity with the neonatal Fc receptor
BT Walters, PF Jensen, V Larraillet, K Lin, T Patapoff, T Schlothauer, ...
Journal of Biological Chemistry 291 (4), 1817-1825, 2016
Multiscale coarse-grained approach to investigate self-association of antibodies
S Izadi, TW Patapoff, BT Walters
Biophysical journal 118 (11), 2741-2754, 2020
Dissecting the molecular basis of high viscosity of monospecific and bispecific IgG antibodies
C Tilegenova, S Izadi, J Yin, CS Huang, J Wu, D Ellerman, SG Hymowitz, ...
MAbs 12 (1), 1692764, 2020
Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands
E Ferri, A Le Thomas, HA Wallweber, ES Day, BT Walters, SE Kaufman, ...
Nature Communications 11 (1), 6387, 2020
Empirical method to accurately determine peptide-averaged protection factors from hydrogen exchange MS data
BT Walters
Analytical chemistry 89 (2), 1049-1053, 2017
Bivalent antibody pliers inhibit β-tryptase by an allosteric mechanism dependent on the IgG hinge
HR Maun, R Vij, BT Walters, A Morando, JK Jackman, P Wu, A Estevez, ...
Nature Communications 11 (1), 6435, 2020
Structure-based correlation of light-induced histidine reactivity in a model protein
M Lei, T Carcelen, BT Walters, C Zamiri, C Quan, Y Hu, J Nishihara, H Yip, ...
Analytical chemistry 89 (13), 7225-7231, 2017
High-Throughput Kinetic Characterization of Irreversible Covalent Inhibitors of KRASG12C by Intact Protein MS and Targeted MRM
KS Li, JG Quinn, MJ Saabye, JFS Guerrero, J Nonomiya, Q Lian, ...
Analytical Chemistry 94 (2), 1230-1239, 2022
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