Anthony William Paul Fitzpatrick

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Michele VendruscoloProfessor of Biophysics, University of CambridgeVerified email at cam.ac.uk
Christopher DobsonUniversity of CambridgeVerified email at cam.ac.uk
Tuomas KnowlesProfessor of Physical Chemistry and Biophysics, University of CambridgeVerified email at cam.ac.uk
Chris WaudbyUCL School of PharmacyVerified email at ucl.ac.uk
Sjors ScheresMRC Laboratory of Molecular BiologyVerified email at mrc-lmb.cam.ac.uk
Sarah MeehanErasmus Medical CentreVerified email at erasmusmc.nl
Carlomagno YariMayo clinicVerified email at mayo.edu
Dennis W. DicksonMayo ClinicVerified email at mayo.edu
Michel GoedertMRC Laboratory of Molecular Biology, Cambridge, UKVerified email at mrc-lmb.cam.ac.uk
Garib N MurshudovGroup Leader, MRC Laboratory of Molecular BiologyVerified email at mrc-lmb.cam.ac.uk
Holly GarringerIndiana UniversityVerified email at iu.edu
Dr Helen MottVerified email at cam.ac.uk
Tamta ArakhamiaGraduate, Columbia University in the City of New YorkVerified email at columbia.edu
Vikram S. BajajForesite Capital, Foresite Labs, Stanford Medical School, UC BerkeleyVerified email at berkeley.edu
Robert G. GriffinProfessor of Chemistry, MITVerified email at mit.edu
Marc A CaporiniModernaVerified email at modernatx.com
Benjamin Ryskeldi-FalconGroup Leader, MRC Laboratory of Molecular Biology (LMB)Verified email at mrc-lmb.cam.ac.uk
Vladimir LadizhanskyProfessor of Biophysics, University of GuelphVerified email at uoguelph.ca
Christopher JaroniecProfessor of Chemistry & Biochemistry, The Ohio State UniversityVerified email at chemistry.ohio-state.edu
Marvin J BayroAssistant Professor, University of Puerto Rico, Rio Piedras CampusVerified email at upr.edu

Anthony William Paul Fitzpatrick

Assistant Professor, Department of Biochemistry & Molecular Biophysics, Columbia University, NYC

Verified email at columbia.edu - Homepage

Neuroscience Biophysics Structural Biology Cryo-EM Cryo-ET


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Cryo-EM structures of tau filaments from Alzheimer’s disease AWP Fitzpatrick, B Falcon, S He, AG Murzin, G Murshudov, HJ Garringer, ... Nature 547 (7662), 185-190, 2017	1990	2017
Role of intermolecular forces in defining material properties of protein nanofibrils TP Knowles, AW Fitzpatrick, S Meehan, HR Mott, M Vendruscolo, ... science 318 (5858), 1900-1903, 2007	894	2007
Atomic structure and hierarchical assembly of a cross-β amyloid fibril AWP Fitzpatrick, GT Debelouchina, MJ Bayro, DK Clare, MA Caporini, ... Proceedings of the National Academy of Sciences 110 (14), 5468-5473, 2013	685	2013
Metastability of native proteins and the phenomenon of amyloid formation AJ Baldwin, TPJ Knowles, GG Tartaglia, AW Fitzpatrick, GL Devlin, ... Journal of the American Chemical Society 133 (36), 14160-14163, 2011	521	2011
Posttranslational modifications mediate the structural diversity of tauopathy strains T Arakhamia, CE Lee, Y Carlomagno, M Kumar, DM Duong, H Wesseling, ... Cell 180 (4), 633-644. e12, 2020	377	2020
Structure of the MacAB-TolC ABC-type tripartite multidrug efflux pump AWP Fitzpatrick, S Llabrés, A Neuberger, JN Blaza, XC Bai, U Okada, ... Nature Microbiology 2, 17070, 2017	193	2017
Cryo-EM of amyloid fibrils and cellular aggregates AWP Fitzpatrick, HR Saibil Current opinion in structural biology 58, 34-42, 2019	144	2019
Inversion of the balance between hydrophobic and hydrogen bonding interactions in protein folding and aggregation AW Fitzpatrick, TPJ Knowles, CA Waudby, M Vendruscolo, CM Dobson PLoS computational biology 7 (10), e1002169, 2011	124	2011
Bottom-up structural proteomics: cryoEM of protein complexes enriched from the cellular milieu CM Ho, X Li, M Lai, TC Terwilliger, JR Beck, J Wohlschlegel, DE Goldberg, ... Nature methods 17 (1), 79-85, 2020	112	2020
In-cell NMR characterization of the secondary structure populations of a disordered conformation of α-synuclein within E. coli cells CA Waudby, C Camilloni, AWP Fitzpatrick, LD Cabrita, CM Dobson, ... PloS one 8 (8), e72286, 2013	111	2013
Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases A Chang, X Xiang, J Wang, C Lee, T Arakhamia, M Simjanoska, C Wang, ... Cell 185 (8), 1346-1355. e15, 2022	110	2022
Exceptional rigidity and biomechanics of amyloid revealed by 4D electron microscopy AWP Fitzpatrick, ST Park, AH Zewail Proceedings of the National Academy of Sciences 110 (27), 10976-10981, 2013	104	2013
Higher order amyloid fibril structure by MAS NMR and DNP spectroscopy GT Debelouchina, MJ Bayro, AW Fitzpatrick, V Ladizhansky, MT Colvin, ... Journal of the American Chemical Society 135 (51), 19237-19247, 2013	101	2013
Four-dimensional electron microscopy: Ultrafast imaging, diffraction and spectroscopy in materials science and biology GM Vanacore, AWP Fitzpatrick, AH Zewail Nano Today 11 (2), 228-249, 2016	96	2016
Nanomechanics and intermolecular forces of amyloid revealed by four-dimensional electron microscopy AWP Fitzpatrick, GM Vanacore, AH Zewail Proceedings of the National Academy of Sciences 112 (11), 3380-3385, 2015	61	2015
Twisting transition between crystalline and fibrillar phases of aggregated peptides TPJ Knowles, A De Simone, AW Fitzpatrick, A Baldwin, S Meehan, ... Physical Review Letters 109 (15), 158101, 2012	55	2012
The AD tau core spontaneously self-assembles and recruits full-length tau to filaments Y Carlomagno, S Manne, M DeTure, M Prudencio, YJ Zhang, ... Cell reports 34 (11), 2021	52	2021
4D cryo-electron microscopy of proteins AWP Fitzpatrick, UJ Lorenz, GM Vanacore, AH Zewail Journal of the American Chemical Society 135 (51), 19123-19126, 2013	46	2013
Structures of LRP2 reveal a molecular machine for endocytosis A Beenken, G Cerutti, J Brasch, Y Guo, Z Sheng, H Erdjument-Bromage, ... Cell 186 (4), 821-836. e13, 2023	35	2023
Accurate determination of interstrand distances and alignment in amyloid fibrils by magic angle spinning NMR MA Caporini, VS Bajaj, M Veshtort, A Fitzpatrick, CE MacPhee, ... The Journal of Physical Chemistry B 114 (42), 13555-13561, 2010	35	2010

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