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Laura Morelli
Laura Morelli
CONICET
Dirección de correo verificada de leloir.org.ar
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New insights into the genetic etiology of Alzheimer’s disease and related dementias
C Bellenguez, F Küçükali, IE Jansen, L Kleineidam, S Moreno-Grau, ...
Nature genetics 54 (4), 412-436, 2022
12212022
β-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy
C Soto, EM Sigurdsson, L Morelli, R Asok Kumar, EM Castaño, ...
Nature medicine 4 (7), 822-826, 1998
11191998
Degradation of soluble amyloid β-peptides 1–40, 1–42, and the Dutch variant 1–40Q by insulin degrading enzyme from Alzheimer disease and control brains
A Pérez, L Morelli, JC Cresto, EM Castaño
Neurochemical research 25, 247-255, 2000
3152000
Defective ubiquitination of cerebral proteins in Alzheimer's disease
M López Salon, L Morelli, EM Castano, EF Soto, JM Pasquini
Journal of neuroscience research 62 (2), 302-310, 2000
2692000
Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
I De Rojas, S Moreno-Grau, N Tesi, B Grenier-Boley, V Andrade, ...
Nature communications 12 (1), 3417, 2021
2142021
Insulin-degrading enzyme sorting in exosomes: A secretory pathway for a key brain amyloid-β degrading protease
A Bulloj, MC Leal, H Xu, EM Castaño, L Morelli
Journal of Alzheimer's Disease 19 (1), 79-95, 2010
1642010
Carbohydrates and immunology: synthetic oligosaccharide antigens for vaccine formulation
L Morelli, L Poletti, L Lay
European Journal of Organic Chemistry 2011 (29), 5723-5777, 2011
1352011
Insulin-degrading enzyme: structure-function relationship and its possible roles in health and disease
A Fernandez-Gamba, MC Leal, L Morelli, EM Castaño
Current pharmaceutical design 15 (31), 3644-3655, 2009
1322009
The cell cycle in Alzheimer disease: a unique target for neuropharmacology
KM Webber, AK Raina, MW Marlatt, X Zhu, MI Prat, L Morelli, ...
Mechanisms of ageing and development 126 (10), 1019-1025, 2005
1292005
Differential cerebral deposition of IDE and NEP in sporadic and familial Alzheimer's disease
VB Dorfman, L Pasquini, M Riudavets, JJ López-Costa, A Villegas, ...
Neurobiology of aging 31 (10), 1743-1757, 2010
1092010
Differential degradation of amyloid β genetic variants associated with hereditary dementia or stroke by insulin-degrading enzyme
L Morelli, R Llovera, SA Gonzalez, JL Affranchino, F Prelli, B Frangione, ...
Journal of biological chemistry 278 (26), 23221-23226, 2003
1042003
Dementia in Latin America: paving the way toward a regional action plan
MA Parra, S Baez, L Sedeño, C Gonzalez Campo, H Santamaría‐García, ...
Alzheimer's & Dementia 17 (2), 295-313, 2021
1012021
Plaque-associated overexpression of insulin-degrading enzyme in the cerebral cortex of aged transgenic tg2576 mice with Alzheimer pathology
MC Leal, VB Dorfman, AF Gamba, B Frangione, T Wisniewski, ...
Journal of Neuropathology & Experimental Neurology 65 (10), 976-987, 2006
972006
Longitudinal analysis of the behavioral phenotype in a novel transgenic rat model of early stages of Alzheimer's disease
P Galeano, PV Martino Adami, S Do Carmo, E Blanco, C Rotondaro, ...
Frontiers in behavioral neuroscience 8, 321, 2014
932014
Insulin-degrading enzyme in brain microvessels: proteolysis of amyloid β vasculotropic variants and reduced activity in cerebral amyloid angiopathy
L Morelli, RE Llovera, I Mathov, LF Lue, B Frangione, J Ghiso, ...
Journal of Biological Chemistry 279 (53), 56004-56013, 2004
882004
Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP‐1‐associated regulator of cyclin B, in Alzheimer's disease
X Zhu, A McShea, PLR Harris, AK Raina, RJ Castellani, JO Funk, S Shah, ...
Journal of neuroscience research 75 (5), 698-703, 2004
852004
Activation of Hsp90 enzymatic activity and conformational dynamics through rationally designed allosteric ligands
S Sattin, J Tao, G Vettoretti, E Moroni, M Pennati, A Lopergolo, L Morelli, ...
Chemistry–A European Journal 21 (39), 13598-13608, 2015
782015
Structure of the type IX group B Streptococcus capsular polysaccharide and its evolutionary relationship with types V and VII
F Berti, E Campisi, C Toniolo, L Morelli, S Crotti, R Rosini, MR Romano, ...
Journal of Biological Chemistry 289 (34), 23437-23448, 2014
762014
New insights on the genetic etiology of Alzheimer’s and related dementia
C Bellenguez, F Küçükali, I Jansen, V Andrade, S Moreno-Grau, N Amin, ...
MedRxiv, 2020.10. 01.20200659, 2020
732020
Detergent resistant membrane-associated IDE in brain tissue and cultured cells: Relevance to Aβ and insulin degradation
A Bulloj, MC Leal, EI Surace, X Zhang, H Xu, MD Ledesma, EM Castaño, ...
Molecular neurodegeneration 3, 1-13, 2008
642008
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Artículos 1–20