Production of soluble αβ T-cell receptor heterodimers suitable for biophysical analysis of ligand binding BE Willcox, GF Gao, JR Wyer, CA O'callaghan, JM Boulter, EY Jones, ... Protein Science 8 (11), 2418-2423, 1999 | 767 | 1999 |
Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G M Shiroishi, K Tsumoto, K Amano, Y Shirakihara, M Colonna, VM Braud, ... Proceedings of the National Academy of Sciences 100 (15), 8856-8861, 2003 | 672 | 2003 |
Complex structure of the activating immunoreceptor NKG2D and its MHC class I–like ligand MICA P Li, DL Morris, BE Willcox, A Steinle, T Spies, RK Strong Nature immunology 2 (5), 443-451, 2001 | 502 | 2001 |
Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors AL Hopkins, J Ren, RM Esnouf, BE Willcox, EY Jones, C Ross, ... Journal of Medicinal Chemistry 39 (8), 1589-1600, 1996 | 431 | 1996 |
TCR binding to peptide-MHC stabilizes a flexible recognition interface BE Willcox, GF Gao, JR Wyer, JE Ladbury, JI Bell, BK Jakobsen, ... Immunity 10 (3), 357-365, 1999 | 384 | 1999 |
Cytomegalovirus and tumor stress surveillance by binding of a human γδ T cell antigen receptor to endothelial protein C receptor CR Willcox, V Pitard, S Netzer, L Couzi, M Salim, T Silberzahn, JF Moreau, ... Nature immunology 13 (9), 872-879, 2012 | 340 | 2012 |
Crystal structure of HLA-A2 bound to LIR-1, a host and viral major histocompatibility complex receptor BE Willcox, LM Thomas, PJ Bjorkman Nature immunology 4 (9), 913-919, 2003 | 314 | 2003 |
Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance MS Davey, CR Willcox, SP Joyce, K Ladell, SA Kasatskaya, JE McLaren, ... Nature communications 8 (1), 14760, 2017 | 252 | 2017 |
T cell receptor and coreceptor CD8αα bind peptide-MHC independently and with distinct kinetics JR Wyer, BE Willcox, GF Gao, UC Gerth, SJ Davis, JI Bell, ... Immunity 10 (2), 219-225, 1999 | 235 | 1999 |
Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E CA O'Callaghan, J Tormo, BE Willcox, VM Braud, BK Jakobsen, DI Stuart, ... Molecular cell 1 (4), 531-541, 1998 | 223 | 1998 |
Butyrophilin-2A1 directly binds germline-encoded regions of the Vγ9Vδ2 TCR and is essential for phosphoantigen sensing MM Karunakaran, CR Willcox, M Salim, D Paletta, AS Fichtner, A Noll, ... Immunity 52 (3), 487-498. e6, 2020 | 196 | 2020 |
The human Vδ2+ T-cell compartment comprises distinct innate-like Vγ9+ and adaptive Vγ9- subsets MS Davey, CR Willcox, S Hunter, SA Kasatskaya, EBM Remmerswaal, ... Nature communications 9 (1), 1760, 2018 | 193 | 2018 |
Classical and nonclassical class I major histocompatibility complex molecules exhibit subtle conformational differences that affect binding to CD8αα GF Gao, BE Willcox, JR Wyer, JM Boulter, CA O'Callaghan, K Maenaka, ... Journal of Biological Chemistry 275 (20), 15232-15238, 2000 | 171 | 2000 |
Phosphorylation-dependent interaction between antigenic peptides and MHC class I: a molecular basis for the presentation of transformed self F Mohammed, M Cobbold, AL Zarling, M Salim, GA Barrett-Wilt, ... Nature immunology 9 (11), 1236-1243, 2008 | 153 | 2008 |
Molecular competition for NKG2D: H60 and RAE1 compete unequally for NKG2D with dominance of H60 CA O'Callaghan, A Cerwenka, BE Willcox, LL Lanier, PJ Bjorkman Immunity 15 (2), 201-211, 2001 | 144 | 2001 |
BirA enzyme: production and application in the study of membrane receptor–ligand interactions by site-specific biotinylation CA O'Callaghan, MF Byford, JR Wyer, BE Willcox, BK Jakobsen, ... Analytical biochemistry 266 (1), 9-15, 1999 | 144 | 1999 |
γδ TCR ligands: the quest to solve a 500-million-year-old mystery BE Willcox, CR Willcox Nature immunology 20 (2), 121-128, 2019 | 136 | 2019 |
Sensing of cell stress by human γδ TCR-dependent recognition of annexin A2 R Marlin, A Pappalardo, H Kaminski, CR Willcox, V Pitard, S Netzer, ... Proceedings of the National Academy of Sciences 114 (12), 3163-3168, 2017 | 129 | 2017 |
Butyrophilin-like 3 directly binds a human Vγ4+ T cell receptor using a modality distinct from clonally-restricted antigen CR Willcox, P Vantourout, M Salim, I Zlatareva, D Melandri, L Zanardo, ... Immunity 51 (5), 813-825. e4, 2019 | 128 | 2019 |
Human liver infiltrating γδ T cells are composed of clonally expanded circulating and tissue-resident populations S Hunter, CR Willcox, MS Davey, SA Kasatskaya, HC Jeffery, ... Journal of hepatology 69 (3), 654-665, 2018 | 128 | 2018 |