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Samuel Sparks
Samuel Sparks
Roivant Sciences
Verified email at roivant.com
Title
Cited by
Cited by
Year
The molecular mechanism of nuclear transport revealed by atomic-scale measurements
LE Hough, K Dutta, S Sparks, DB Temel, A Kamal, J Tetenbaum-Novatt, ...
Elife 4, e10027, 2015
1572015
Mechanistic studies of peptide self-assembly: transient α-helices to stable β-sheets
G Liu, A Prabhakar, D Aucoin, M Simon, S Sparks, KJ Robbins, A Sheen, ...
Journal of the American Chemical Society 132 (51), 18223-18232, 2010
942010
Curcumin modulates the self-assembly of the islet amyloid polypeptide by disassembling α-helix
S Sparks, G Liu, KJ Robbins, ND Lazo
Biochemical and biophysical research communications 422 (4), 551-555, 2012
792012
Thermodynamic characterization of the multivalent interactions underlying rapid and selective translocation through the nuclear pore complex
R Hayama, S Sparks, LM Hecht, K Dutta, JM Karp, CM Cabana, MP Rout, ...
Journal of Biological Chemistry 293 (12), 4555-4563, 2018
572018
Controlling lipid micelle stability using oligonucleotide headgroups
SE Wilner, SE Sparks, D Cowburn, ME Girvin, M Levy
Journal of the American Chemical Society 137 (6), 2171-2174, 2015
272015
Deciphering the “fuzzy” interaction of FG nucleoporins and transport factors using small-angle neutron scattering
S Sparks, DB Temel, MP Rout, D Cowburn
Structure 26 (3), 477-484. e4, 2018
212018
Effects of FGFR2 kinase activation loop dynamics on catalytic activity
JM Karp, S Sparks, D Cowburn
PLoS computational biology 13 (2), e1005360, 2017
142017
Design of a systemic small molecule clinical STING agonist using physics-based simulations and artificial intelligence
BK Allen, MM Kulkarni, B Chamberlain, T Dwight, C Koh, R Samant, ...
Biorxiv, 2022.05. 23.493001, 2022
102022
Analysis of multivalent IDP interactions: stoichiometry, affinity, and local concentration effect measurements
S Sparks, R Hayama, MP Rout, D Cowburn
Intrinsically Disordered Proteins: Methods and Protocols, 463-475, 2020
22020
Abstract LB-A20: True small molecule STING agonist generates systemic and potent anti-tumor immunity required for effective cancer immunotherapy
MM Kulkarni, T Dwight, K Marino, BK Allen, M Taimi, C Bastos, S Lai, ...
Molecular Cancer Therapeutics 18 (12_Supplement), LB-A20-LB-A20, 2019
2019
True small molecule STING agonist generates systemic and potent anti-tumor immunity required for effective cancer immunotherapy
MM Kulkarni, T Dwight, K Marino, BK Allen, M Taimi, C Bastos, S Lai, ...
MOLECULAR CANCER THERAPEUTICS 18 (12), 2019
2019
Tackling challenging targets in innate immune pathways with integrated biophysics and simulation
H Soutter, I Kolossvary, K Marino, S Sparks, H Xu, W Sherman
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 258, 2019
2019
Deciphering the'fuzzy'interaction of FG nucleoporins and transport factors using SANS
D Cowburn, S Sparks, DB Temel, MP Rout
Acta Crystallographica Section A: Foundations and Advances 75, a395-a395, 2019
2019
Thermodynamics of The Interactions of FG‐Nucleoporins and Transport Factors
S Sparks, R Hayama, MP Rout, D Cowburn
The FASEB Journal 32, lb58-lb58, 2018
2018
The [alpha]-helix in Maturing Assemblies of the Islet Amyloid Polypeptide is Susceptible to Unfolding by Biphenols
S Sparks
Clark University, 2011
2011
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