| Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17 CD Chen, S Podvin, E Gillespie, SE Leeman, CR Abraham Proceedings of the National Academy of Sciences 104 (50), 19796-19801, 2007 | 654 | 2007 |
| Enhanced prime editing systems by manipulating cellular determinants of editing outcomes PJ Chen, JA Hussmann, J Yan, F Knipping, P Ravisankar, PF Chen, ... Cell 184 (22), 5635-5652. e29, 2021 | 416 | 2021 |
| The neuroprotective effect of Klotho is mediated via regulation of members of the redox system E Zeldich, CD Chen, TA Colvin, EA Bove-Fenderson, J Liang, TBT Zhou, ... Journal of Biological Chemistry 289 (35), 24700-24715, 2014 | 222 | 2014 |
| The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS CD Chen, JA Sloane, H Li, N Aytan, EL Giannaris, E Zeldich, JD Hinman, ... Journal of Neuroscience 33 (5), 1927-1939, 2013 | 191 | 2013 |
| Furin initiates gelsolin familial amyloidosis in the Golgi through a defect in Ca2+ stabilization CD Chen, ME Huff, J Matteson, L Page, R Phillips, JW Kelly, WE Balch The EMBO journal, 2001 | 150 | 2001 |
| Identification of cleavage sites leading to the shed form of the anti-aging protein klotho CD Chen, TY Tung, J Liang, E Zeldich, TB Tucker Zhou, BE Turk, ... Biochemistry 53 (34), 5579-5587, 2014 | 144 | 2014 |
| The Cytoplasmic and N-terminal Transmembrane Domains of Cytochrome P450 Contain Independent Signals for Retention in the Endoplasmic Reticulum (∗) E Szczesna-Skorupa, K Ahn, CD Chen, B Doray, B Kemper Journal of Biological Chemistry 270 (41), 24327-24333, 1995 | 89 | 1995 |
| Klotho is a neuroprotective and cognition-enhancing protein CR Abraham, PC Mullen, T Tucker-Zhou, CD Chen, E Zeldich Vitamins & hormones 101, 215-238, 2016 | 84 | 2016 |
| Mobility of cytochrome P450 in the endoplasmic reticulum membrane E Szczesna-Skorupa, CD Chen, S Rogers, B Kemper Proceedings of the National Academy of Sciences 95 (25), 14793-14798, 1998 | 80 | 1998 |
| Visualization of APP dimerization and APP‐Notch2 heterodimerization in living cells using bimolecular fluorescence complementation CD Chen, SY Oh, JD Hinman, CR Abraham Journal of neurochemistry 97 (1), 30-43, 2006 | 79 | 2006 |
| PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation G Jun, H Asai, E Zeldich, E Drapeau, CD Chen, J Chung, JH Park, S Kim, ... Annals of neurology 76 (3), 379-392, 2014 | 74 | 2014 |
| Stability of RNA from the retina and retinal pigment epithelium in a porcine model simulating human eye bank conditions KJ Malik, CD Chen, TW Olsen Investigative ophthalmology & visual science 44 (6), 2730-2735, 2003 | 69 | 2003 |
| Gene expression changes associated with the endoplasmic reticulum stress response induced by microsomal cytochrome p450 overproduction E Szczesna-Skorupa, CD Chen, H Liu, B Kemper Journal of Biological Chemistry 279 (14), 13953-13961, 2004 | 67 | 2004 |
| Small-molecule Klotho enhancers as novel treatment of neurodegeneration CR Abraham, CD Chen, GD Cuny, MA Glicksman, E Zeldich Future medicinal chemistry 4 (13), 1671-1679, 2012 | 66 | 2012 |
| Identification of novel small molecules that elevate Klotho expression GD King, CD Chen, MM Huang, E Zeldich, PL Brazee, ER Schuman, ... Biochemical Journal 441 (1), 453-461, 2012 | 65 | 2012 |
| The anti-aging protein Klotho enhances remyelination following cuprizone-induced demyelination E Zeldich, CD Chen, R Avila, S Medicetty, CR Abraham Journal of Molecular Neuroscience 57, 185-196, 2015 | 64 | 2015 |
| The anti-aging and tumor suppressor protein Klotho enhances differentiation of a human oligodendrocytic hybrid cell line CD Chen, H Li, J Liang, K Hixson, E Zeldich, CR Abraham Journal of Molecular Neuroscience 55, 76-90, 2015 | 64 | 2015 |
| Age‐dependent accumulation of ubiquitinated 2′, 3′‐cyclic nucleotide 3′‐phosphodiesterase in myelin lipid rafts JD Hinman, CD Chen, SY Oh, W Hollander, CR Abraham Glia 56 (1), 118-133, 2008 | 59 | 2008 |
| Amyloid precursor protein interacts with notch receptors SY Oh, A Ellenstein, CD Chen, JD Hinman, EA Berg, CE Costello, ... Journal of neuroscience research 82 (1), 32-42, 2005 | 58 | 2005 |
| Identification and localization of major soluble vitreous proteins in human ocular tissue CW Wu, JL Sauter, PK Johnson, CD Chen, TW Olsen American journal of ophthalmology 137 (4), 655-661, 2004 | 57 | 2004 |
Makoto Kuro-oJichi Medical UniversityVerified email at jichi.ac.jp
