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Marcelo Comini
Marcelo Comini
Principal Investigator, Institut Pasteur de Montevideo, Uruguay
Dirección de correo verificada de pasteur.edu.uy - Página principal
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Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism
RL Krauth-Siegel, MA Comini
Biochimica et Biophysica Acta (BBA)-General Subjects 1780 (11), 1236-1248, 2008
4862008
Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxification
F Irigoín, L Cibils, MA Comini, SR Wilkinson, L Flohé, R Radi
Free Radical Biology and Medicine 45 (6), 733-742, 2008
1952008
Identification of novel bacterial plasminogen‐binding proteins in the human pathogen Mycobacterium tuberculosis
W Xolalpa, AJ Vallecillo, M Lara, G Mendoza‐Hernandez, M Comini, ...
Proteomics 7 (18), 3332-3341, 2007
1512007
Validation of Trypanosoma brucei trypanothione synthetase as drug target
MA Comini, SA Guerrero, S Haile, U Menge, H Lünsdorf, L Flohé
Free Radical Biology and Medicine 36 (10), 1289-1302, 2004
1432004
Trypanothione: a unique bis-glutathionyl derivative in trypanosomatids
B Manta, M Comini, A Medeiros, M Hugo, M Trujillo, R Radi
Biochimica et Biophysica Acta (BBA)-General Subjects 1830 (5), 3199-3216, 2013
1412013
Depletion of the thioredoxin homologue tryparedoxin impairs antioxidative defence in African trypanosomes
MA Comini, RL Krauth-Siegel, L Flohé
Biochemical Journal 402 (1), 43-49, 2007
1122007
New organoruthenium complexes with bioactive thiosemicarbazones as co-ligands: potential anti-trypanosomal agents
B Demoro, C Sarniguet, R Sánchez-Delgado, M Rossi, D Liebowitz, ...
Dalton Transactions 41 (5), 1534-1543, 2012
1012012
The trypanothione system
LR Krauth-Siegel, MA Comini, T Schlecker
Peroxiredoxin Systems: Structures and Functions, 231-251, 2007
992007
Measurement and meaning of cellular thiol: disufhide redox status
MA Comini
Free radical research 50 (2), 246-271, 2016
882016
Evaluation of the diagnostic value of measuring IgG, IgM and IgA antibodies to the recombinant 16-kilodalton antigen of Mycobacterium tuberculosis in childhood tuberculosis
S Imaz M, A Comini M, E Zerbini, D Sequeira M, J Spoletti M, A Etchart A, ...
The International Journal of Tuberculosis and Lung Disease 5 (11), 1036-1043, 2001
842001
Monothiol glutaredoxin-1 is an essential iron-sulfur protein in the mitochondrion of African trypanosomes
MA Comini, J Rettig, N Dirdjaja, EM Hanschmann, C Berndt, ...
Journal of biological chemistry 283 (41), 27785-27798, 2008
802008
Trypanothione synthesis in Crithidia revisited
M Comini, U Menge, J Wissing, L Flohé
Journal of Biological Chemistry 280 (8), 6850-6860, 2005
722005
Oxidovanadium (IV) and dioxidovanadium (V) complexes of tridentate salicylaldehyde semicarbazones: searching for prospective antitrypanosomal agents
M Fernández, L Becco, I Correia, J Benítez, OE Piro, GA Echeverria, ...
Journal of Inorganic Biochemistry 127, 150-160, 2013
672013
Catalytic mechanism of the glutathione peroxidase-type tryparedoxin peroxidase of Trypanosoma brucei
T Schlecker, MA Comini, J Melchers, T Ruppert, RL Krauth-Siegel
Biochemical Journal 405 (3), 445-454, 2007
672007
Identification of novel chemical scaffolds inhibiting trypanothione synthetase from pathogenic trypanosomatids
D Benítez, A Medeiros, L Fiestas, EA Panozzo-Zenere, F Maiwald, ...
PLoS neglected tropical diseases 10 (4), e0004617, 2016
662016
Biosynthesis of trypanothione in Trypanosoma brucei brucei
M Comini, U Menge, L Flohé
Walter de Gruyter 384 (4), 653-656, 2003
612003
Determination of acidity and nucleophilicity in thiols by reaction with monobromobimane and fluorescence detection
F Sardi, B Manta, S Portillo-Ledesma, B Knoops, MA Comini, ...
Analytical Biochemistry 435 (1), 74-82, 2013
592013
Genetic and chemical analyses reveal that trypanothione synthetase but not glutathionylspermidine synthetase is essential for Leishmania infantum
AF Sousa, AG Gomes-Alves, D Benítez, MA Comini, L Flohé, T Jaeger, ...
Free Radical Biology and Medicine 73, 229-238, 2014
562014
The mycobacterial thioredoxin peroxidase can act as a one-cysteine peroxiredoxin
M Trujillo, PL Mauri, L Benazzi, M Comini, A De Palma, L Flohé, R Radi, ...
Journal of biological chemistry 281 (29), 20555-20566, 2006
552006
Cloning, functional analysis, and mitochondrial localization of Trypanosoma brucei monothiol glutaredoxin-1
M Filser, MA Comini, MM Molina-Navarro, N Dirdjaja, E Herrero, ...
Walter de Gruyter 389 (1), 21-32, 2008
542008
El sistema no puede realizar la operación en estos momentos. Inténtalo de nuevo más tarde.
Artículos 1–20