| Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 EL Mills, DG Ryan, HA Prag, D Dikovskaya, D Menon, Z Zaslona, ... Nature 556 (7699), 113-117, 2018 | 1275 | 2018 |
| Exosome-delivered microRNAs modulate the inflammatory response to endotoxin M Alexander, R Hu, MC Runtsch, DA Kagele, TL Mosbruger, ... Nature communications 6 (1), 7321, 2015 | 735 | 2015 |
| The immunomodulatory metabolite itaconate modifies NLRP3 and inhibits inflammasome activation A Hooftman, S Angiari, S Hester, SE Corcoran, MC Runtsch, C Ling, ... Cell metabolism 32 (3), 468-478. e7, 2020 | 329 | 2020 |
| Pharmacological activation of pyruvate kinase M2 inhibits CD4+ T cell pathogenicity and suppresses autoimmunity S Angiari, MC Runtsch, CE Sutton, EM Palsson-McDermott, B Kelly, ... Cell metabolism 31 (2), 391-405. e8, 2020 | 199 | 2020 |
| Epistasis between microRNAs 155 and 146a during T cell-mediated antitumor immunity TB Huffaker, R Hu, MC Runtsch, E Bake, X Chen, J Zhao, JL Round, ... Cell reports 2 (6), 1697-1709, 2012 | 188 | 2012 |
| miR-155 promotes T follicular helper cell accumulation during chronic, low-grade inflammation R Hu, DA Kagele, TB Huffaker, MC Runtsch, M Alexander, J Liu, E Bake, ... Immunity 41 (4), 605-619, 2014 | 170 | 2014 |
| Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages MC Runtsch, S Angiari, A Hooftman, R Wadhwa, Y Zhang, Y Zheng, ... Cell metabolism 34 (3), 487-501. e8, 2022 | 129 | 2022 |
| MicroRNA-155 confers encephalogenic potential to Th17 cells by promoting effector gene expression R Hu, TB Huffaker, DA Kagele, MC Runtsch, E Bake, AA Chaudhuri, ... The Journal of Immunology 190 (12), 5972-5980, 2013 | 119 | 2013 |
| MicroRNAs and the regulation of intestinal homeostasis MC Runtsch, JL Round, RM O’Connell Frontiers in genetics 5, 104000, 2014 | 97 | 2014 |
| Rab27-dependent exosome production inhibits chronic inflammation and enables acute responses to inflammatory stimuli M Alexander, AG Ramstead, KM Bauer, SH Lee, MC Runtsch, J Wallace, ... The Journal of Immunology 199 (10), 3559-3570, 2017 | 84 | 2017 |
| Antitumor immunity is defective in T cell–specific microRNA-155–deficient mice and is rescued by immune checkpoint blockade TB Huffaker, SH Lee, WW Tang, JA Wallace, M Alexander, MC Runtsch, ... Journal of Biological Chemistry 292 (45), 18530-18541, 2017 | 72 | 2017 |
| Glutathione transferase omega-1 regulates NLRP3 inflammasome activation through NEK7 deglutathionylation MM Hughes, A Hooftman, S Angiari, P Tummala, Z Zaslona, MC Runtsch, ... Cell reports 29 (1), 151-161. e5, 2019 | 66 | 2019 |
| MyD88 regulates physical inactivity-induced skeletal muscle inflammation, ceramide biosynthesis signaling, and glucose intolerance OS Kwon, RE Tanner, KM Barrows, M Runtsch, JD Symons, T Jalili, ... American Journal of Physiology-Endocrinology and Metabolism 309 (1), E11-E21, 2015 | 66 | 2015 |
| miR-155 promotes FLT3-ITD–induced myeloproliferative disease through inhibition of the interferon response JA Wallace, DA Kagele, AM Eiring, CN Kim, R Hu, MC Runtsch, ... Blood, The Journal of the American Society of Hematology 129 (23), 3074-3086, 2017 | 64 | 2017 |
| MicroRNA-146a constrains multiple parameters of intestinal immunity and increases susceptibility to DSS colitis MC Runtsch, R Hu, M Alexander, J Wallace, D Kagele, C Petersen, ... Oncotarget 6 (30), 28556, 2015 | 60 | 2015 |
| Anti-inflammatory microRNA-146a protects mice from diet-induced metabolic disease MC Runtsch, MC Nelson, SH Lee, W Voth, M Alexander, R Hu, J Wallace, ... PLoS genetics 15 (2), e1007970, 2019 | 55 | 2019 |
| A Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages TB Huffaker, HA Ekiz, C Barba, SH Lee, MC Runtsch, MC Nelson, ... Nature communications 12 (1), 2620, 2021 | 37 | 2021 |
| GOTcha: lncRNA-ACOD1 targets metabolism during viral infection MC Runtsch, LAJ O'Neill Cell Research 28 (2), 137-138, 2018 | 16 | 2018 |
| Exosome-delivered microRNAs modulate the inflammatory response to endotoxin. Nat Commun. 2015; 6: 7321 M Alexander, R Hu, MC Runtsch, DA Kagele, TL Mosbruger, ... Cell Physiol Biochem 46, 1555-1565, 2018 | 13 | 2018 |
| Metabolic determinants of leukocyte pathogenicity in neurological diseases MC Runtsch, G Ferrara, S Angiari Journal of neurochemistry 158 (1), 36-58, 2021 | 12 | 2021 |
Ryan M. O'ConnellProfessor of Pathology, University of UtahDirección de correo verificada de path.utah.edu
