RNA buffers the phase separation behavior of prion-like RNA binding proteins S Maharana, J Wang, DK Papadopoulos, D Richter, A Pozniakovsky, ... Science 360 (6391), 918-921, 2018 | 891 | 2018 |
FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy L Marrone, HCA Drexler, J Wang, P Tripathi, T Distler, P Heisterkamp, ... Acta neuropathologica 138, 67-84, 2019 | 103 | 2019 |
Isogenic FUS-eGFP iPSC reporter lines enable quantification of FUS stress granule pathology that is rescued by drugs inducing autophagy L Marrone, I Poser, I Casci, J Japtok, P Reinhardt, A Janosch, C Andree, ... Stem cell reports 10 (2), 375-389, 2018 | 97 | 2018 |
Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease RJ Wheeler, HO Lee, I Poser, A Pal, T Doeleman, S Kishigami, S Kour, ... | 86 | 2019 |
Dual inhibition of GSK3β and CDK5 protects the cytoskeleton of neurons from neuroinflammatory-mediated degeneration in vitro and in vivo L Reinhardt, S Kordes, P Reinhardt, M Glatza, M Baumann, HCA Drexler, ... Stem cell reports 12 (3), 502-517, 2019 | 50 | 2019 |
Brain oxygen tension controls the expansion of outer subventricular zone-like basal progenitors in the developing mouse brain L Wagenführ, AK Meyer, L Braunschweig, L Marrone, A Storch Development 142 (17), 2904-2915, 2015 | 42 | 2015 |
Proteostatic imbalance and protein spreading in amyotrophic lateral sclerosis ME Cicardi, L Marrone, M Azzouz, D Trotti The EMBO journal 40 (10), e106389, 2021 | 36 | 2021 |
Oxygen tension within the neurogenic niche regulates dopaminergic neurogenesis in the developing midbrain L Wagenführ, AK Meyer, L Marrone, A Storch Stem Cells and Development 25 (3), 227-238, 2016 | 34 | 2016 |
Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization I Casci, K Krishnamurthy, S Kour, V Tripathy, N Ramesh, EN Anderson, ... Nature Communications 10 (1), 5583, 2019 | 32 | 2019 |
Generation of iPSCs carrying a common LRRK2 risk allele for in vitro modeling of idiopathic Parkinson's disease L Marrone, C Bus, D Schöndorf, JC Fitzgerald, M Kübler, B Schmid, ... PloS one 13 (3), e0192497, 2018 | 29 | 2018 |
Circumventing the packaging limit of AAV-mediated gene replacement therapy for neurological disorders L Marrone, PM Marchi, M Azzouz Expert Opinion on Biological Therapy 22 (9), 1163-1176, 2022 | 25 | 2022 |
Primary Spinal OPC Culture System from Adult Zebrafish to Study Oligodendrocyte Differentiation In Vitro V Kroehne, V Tsata, L Marrone, C Froeb, S Reinhardt, A Gompf, A Dahl, ... Frontiers in Cellular Neuroscience 11, 284, 2017 | 18 | 2017 |
C9ORF72-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons PM Marchi, L Marrone, L Brasseur, A Coens, CP Webster, L Bousset, ... Life Science Alliance 5 (9), 2022 | 10 | 2022 |
Adoptive T-cell therapy in the treatment of viral and opportunistic fungal infections N Mancini, L Marrone, N Clementi, GA Sautto, M Clementi, R Burioni Future microbiology 10 (4), 665-682, 2015 | 10 | 2015 |
SPG15 protein deficits are at the crossroads between lysosomal abnormalities, altered lipid metabolism and synaptic dysfunction L Marrone, PM Marchi, CP Webster, R Marroccella, I Coldicott, ... Human Molecular Genetics 31 (16), 2693-2710, 2022 | 7 | 2022 |
SMN-deficient cells exhibit increased ribosomal DNA damage E Karyka, NB Ramirez, CP Webster, PM Marchi, EJ Graves, VK Godena, ... Life science alliance 5 (8), 2022 | 7 | 2022 |
P525L promotes the aggregation of FUS by altering its biochemical and biophysical properties L Marrone, S Qamar, B Mannini, P St George-Hyslop, M Vendruscolo Matters 6 (5), e202004000008, 2020 | 6 | 2020 |
Delivery of therapeutic AAV9 vectors via cisterna magna to treat neurological disorders PM Marchi, L Marrone, M Azzouz Trends in Molecular Medicine 28 (1), 79-80, 2022 | 5 | 2022 |
OS12. 1 Editing of IDH1 R132H mutation in human induced pluripotent stem cells to investigate tumor genesis in glioma A Köpp, M Preussler, S Richter, M Heide, L Marrone, J Sterneckert, ... Neuro-Oncology 21 (Suppl 3), iii22, 2019 | 3 | 2019 |
Phenotypic screening using mouse and human stem cell-based models of neuroinflammation and gene expression analysis to study drug responses M Abo-Rady, J Bellmann, M Glatza, L Marrone, L Reinhardt, S Tena, ... Systems Chemical Biology: Methods and Protocols, 21-43, 2019 | 3 | 2019 |