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David Loughrey
David Loughrey
Lead Research Biomedical Engineer, Emory University School of Medicine
Dirección de correo verificada de emory.edu
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Drug delivery systems for RNA therapeutics
K Paunovska, D Loughrey, JE Dahlman
Nature Reviews Genetics 23 (5), 265-280, 2022
5412022
SHAPE-Seq 2.0: systematic optimization and extension of high-throughput chemical probing of RNA secondary structure with next generation sequencing
D Loughrey, KE Watters, AH Settle, JB Lucks
Nucleic acids research 42 (21), e165-e165, 2014
1582014
Carbon-Doped TiO2 and Carbon, Tungsten-Codoped TiO2 through Sol–Gel Processes in the Presence of Melamine Borate: Reflections through Photocatalysis
EM Neville, MJ Mattle, D Loughrey, B Rajesh, M Rahman, JMD MacElroy, ...
The Journal of Physical Chemistry C 116 (31), 16511-16521, 2012
1322012
The centrality of RNA for engineering gene expression
J Chappell, MK Takahashi, S Meyer, D Loughrey, KE Watters, J Lucks
Biotechnology journal 8 (12), 1379-1395, 2013
902013
Non-liver mRNA delivery
D Loughrey, JE Dahlman
Accounts of chemical research 55 (1), 13-23, 2021
782021
Species-dependent in vivo mRNA delivery and cellular responses to nanoparticles
MZC Hatit, MP Lokugamage, CN Dobrowolski, K Paunovska, H Ni, ...
Nature nanotechnology 17 (3), 310-318, 2022
652022
RNA systems biology: uniting functional discoveries and structural tools to understand global roles of RNAs
EJ Strobel, KE Watters, D Loughrey, JB Lucks
Current opinion in biotechnology 39, 182-191, 2016
652016
Using large datasets to understand nanotechnology
K Paunovska, D Loughrey, CD Sago, R Langer, JE Dahlman
Advanced Materials 31 (43), 1902798, 2019
582019
Piperazine-derived lipid nanoparticles deliver mRNA to immune cells in vivo
H Ni, MZC Hatit, K Zhao, D Loughrey, MP Lokugamage, HE Peck, AD Cid, ...
Nature Communications 13 (1), 4766, 2022
572022
Nanoparticles containing constrained phospholipids deliver mRNA to liver immune cells in vivo without targeting ligands
Z Gan, MP Lokugamage, MZC Hatit, D Loughrey, K Paunovska, M Sato, ...
Bioengineering & Translational Medicine, e10161, 2020
472020
Nanoparticle single-cell multiomic readouts reveal that cell heterogeneity influences lipid nanoparticle-mediated messenger RNA delivery
C Dobrowolski, K Paunovska, E Schrader Echeverri, D Loughrey, ...
Nature Nanotechnology 17 (8), 871-879, 2022
402022
Augmented lipid-nanoparticle-mediated in vivo genome editing in the lungs and spleen by disrupting Cas9 activity in the liver
CD Sago, MP Lokugamage, D Loughrey, KE Lindsay, R Hincapie, ...
Nature biomedical engineering 6 (2), 157-167, 2022
382022
The Transcriptional Response to Lung-Targeting Lipid Nanoparticles in Vivo
A Radmand, MP Lokugamage, H Kim, C Dobrowolski, R Zenhausern, ...
Nano letters 23 (3), 993-1002, 2023
232023
Universal Barcoding Predicts In Vivo ApoE-Independent Lipid Nanoparticle Delivery
AJ Da Silva Sanchez, C Dobrowolski, A Cristian, ES Echeverri, K Zhao, ...
Nano Letters 22 (12), 4822-4830, 2022
232022
Nanoparticle stereochemistry-dependent endocytic processing improves in vivo mRNA delivery
MZC Hatit, CN Dobrowolski, MP Lokugamage, D Loughrey, H Ni, C Zurla, ...
Nature Chemistry 15 (4), 508-515, 2023
222023
High-throughput screens identify a lipid nanoparticle that preferentially delivers mRNA to human tumors in vivo
SG Huayamares, MP Lokugamage, R Rab, AJDS Sanchez, H Kim, ...
Journal of Controlled Release, S0168-3659 (23) 00255-9, 2023
212023
Substituting racemic ionizable lipids with stereopure ionizable lipids can increase mRNA delivery
AJDS Sanchez, K Zhao, SG Huayamares, MZC Hatit, MP Lokugamage, ...
Journal of Controlled Release 353, 270-277, 2023
202023
Increased PIP3 activity blocks nanoparticle mRNA delivery
K Paunovska, A Da Silva Sanchez, MT Foster, D Loughrey, EL Blanchard, ...
Science advances 6 (30), eaba5672, 2020
192020
The extent to which lipid nanoparticles require apolipoprotein E and low-density lipoprotein receptor for delivery changes with ionizable lipid structure
K Paunovska, AJ Da Silva Sanchez, MP Lokugamage, D Loughrey, ...
Nano Letters 22 (24), 10025-10033, 2022
132022
Cationic cholesterol-dependent LNP delivery to lung stem cells, the liver, and heart
A Radmand, H Kim, J Beyersdorf, CN Dobrowolski, R Zenhausern, ...
Proceedings of the National Academy of Sciences 121 (11), e2307801120, 2024
32024
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