| Snake venom metalloproteinases: their role in the pathogenesis of local tissue damage JM Gutiérrez, A Rucavado Biochimie 82 (9-10), 841-850, 2000 | 612 | 2000 |
| Hemorrhage induced by snake venom metalloproteinases: biochemical and biophysical mechanisms involved in microvessel damage JM Gutiérrez, A Rucavado, T Escalante, C Díaz Toxicon 45 (8), 997-1011, 2005 | 458 | 2005 |
| Brucella abortus Uses a Stealthy Strategy to Avoid Activation of the Innate Immune System during the Onset of Infection E Barquero-Calvo, E Chaves-Olarte, DS Weiss, C Guzman-Verri, ... PloS one 2 (7), e631, 2007 | 362 | 2007 |
| Key events in microvascular damage induced by snake venom hemorrhagic metalloproteinases T Escalante, A Rucavado, JW Fox, JM Gutiérrez Journal of proteomics 74 (9), 1781-1794, 2011 | 234 | 2011 |
| Neutralization of local tissue damage induced by Bothrops asper (terciopelo) snake venom JM Gutiérrez, G León, G Rojas, B Lomonte, A Rucavado, F Chaves Toxicon 36 (11), 1529-1538, 1998 | 210 | 1998 |
| Experimental pathology of local tissue damage induced by Bothrops asper snake venom JM Gutiérrez, A Rucavado, F Chaves, C Díaz, T Escalante Toxicon 54 (7), 958-975, 2009 | 189 | 2009 |
| Trends in snakebite envenomation therapy: scientific, technological and public health considerations JM Gutierrez, B Lomonte, G León, A Rucavado, F Chaves, Y Angulo Current pharmaceutical design 13 (28), 2935-2950, 2007 | 172 | 2007 |
| Neutralization of proteases from Bothrops snake venoms by the aqueous extract from Casearia sylvestris (Flacourtiaceae) MH Borges, AM Soares, VM Rodrigues, F Oliveira, AM Fransheschi, ... Toxicon 39 (12), 1863-1869, 2001 | 167 | 2001 |
| Experimental pathophysiology of systemic alterations induced by Bothrops asper snake venom JM Gutiérrez, T Escalante, A Rucavado Toxicon 54 (7), 976-987, 2009 | 163 | 2009 |
| Hemorrhage caused by snake venom metalloproteinases: a journey of discovery and understanding JM Gutiérrez, T Escalante, A Rucavado, C Herrera Toxins 8 (4), 93, 2016 | 148 | 2016 |
| Amino acid sequence and crystal structure of BaP1, a metalloproteinase from Bothrops asper snake venom that exerts multiple tissue‐damaging activities L Watanabe, JD Shannon, RH Valente, A Rucavado, A Alape‐Girón, ... Protein science 12 (10), 2273-2281, 2003 | 145 | 2003 |
| Inhibition of local hemorrhage and dermonecrosis induced by Bothrops asper snake venom: effectiveness of early in situ administration of the peptidomimetic metalloproteinase … A Rucavado, T Escalante, A Franceschi, F Chaves, Y Cury, M Ovadia The American journal of tropical medicine and hygiene 63 (5), 313-319, 2000 | 140 | 2000 |
| Local tissue damage induced by BaP1, a metalloproteinase isolated from Bothrops asper (Terciopelo) snake venom A Rucavado, B Lomonte, M Ovadia, JM Gutiérrez Experimental and molecular pathology 63 (3), 186-199, 1995 | 138 | 1995 |
| Blister formation and skin damage induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper. A Rucavado, J Núñez, JM Gutiérrez International journal of experimental pathology 79 (4), 245, 1998 | 137 | 1998 |
| Increments in cytokines and matrix metalloproteinases in skeletal muscle after injection of tissue-damaging toxins from the venom of the snake Bothrops asper A Rucavado, T Escalante, CFP Teixeira, CM Fernándes, C Díaz, ... Mediators of Inflammation 11 (2), 121-128, 2002 | 130 | 2002 |
| Snake Venomics of the Lesser Antillean Pit Vipers Bothrops caribbaeus and Bothrops lanceolatus: Correlation with Toxicological Activities and Immunoreactivity of … JM Gutiérrez, L Sanz, J Escolano, J Fernandez, B Lomonte, Y Angulo, ... Journal of proteome research 7 (10), 4396-4408, 2008 | 127 | 2008 |
| Effectiveness of batimastat, a synthetic inhibitor of matrix metalloproteinases, in neutralizing local tissue damage induced by BaP1, a hemorrhagic metalloproteinase from the … T Escalante, A Franceschi, A Rucavado, JM Gutiérrez Biochemical pharmacology 60 (2), 269-274, 2000 | 119 | 2000 |
| Snake venom metalloproteinases. Biological roles and participation in the pathophysiology of envenomation. T Escalante, A Rucavado, JM Gutiérrez Handbook of venoms and toxins of reptiles, 115-138, 2009 | 105 | 2009 |
| Purification and characterization of BaH4, a hemorrhagic metalloproteinase from the venom of the snake Bothrops asper A Franceschi, A Rucavado, N Mora, JM Gutiérrez Toxicon 38 (1), 63-77, 2000 | 103 | 2000 |
| Inflammatory effects of BaP1 a metalloproteinase isolated from Bothrops asper snake venom: leukocyte recruitment and release of cytokines CM Fernandes, SR Zamuner, JP Zuliani, A Rucavado, JM Gutiérrez, ... Toxicon 47 (5), 549-559, 2006 | 94 | 2006 |
José María GutiérrezProfesor emérito, Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa RicaVerified email at ucr.ac.cr
