Glucosamine inhibits IL-1β-induced NFκB activation in human osteoarthritic chondrocytes R Largo, MA Alvarez-Soria, I Dıez-Ortego, E Calvo, O Sanchez-Pernaute, ... Osteoarthritis and cartilage 11 (4), 290-298, 2003 | 602 | 2003 |
Osteoarthritis associated with estrogen deficiency JA Roman-Blas, S Castañeda, R Largo, G Herrero-Beaumont Arthritis research & therapy 11, 1-14, 2009 | 445 | 2009 |
Subchondral bone as a key target for osteoarthritis treatment S Castañeda, JA Roman-Blas, R Largo, G Herrero-Beaumont Biochemical pharmacology 83 (3), 315-323, 2012 | 357 | 2012 |
Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis M Bellido, L Lugo, JA Roman-Blas, S Castañeda, JR Caeiro, S Dapia, ... Arthritis research & therapy 12, 1-11, 2010 | 289 | 2010 |
Mycophenolate mofetil prevents salt-sensitive hypertension resulting from angiotensin II exposure B Rodríguez-Iturbe, H Pons, Y Quiroz, K Gordon, J Rincón, M Chávez, ... Kidney international 59 (6), 2222-2232, 2001 | 278 | 2001 |
Effects and interactions of endothelin-1 and angiotensin II on matrix protein expression and synthesis and mesangial cell growth D Gómez-Garre, M Ruiz-Ortega, M Ortego, R Largo, MJ López-Armada, ... Hypertension 27 (4), 885-892, 1996 | 239 | 1996 |
TLR4 signalling in osteoarthritis—finding targets for candidate DMOADs R Gómez, A Villalvilla, R Largo, O Gualillo, G Herrero-Beaumont Nature Reviews Rheumatology 11 (3), 159-170, 2015 | 232 | 2015 |
Mycophenolate mofetil prevents salt-sensitive hypertension resulting from nitric oxide synthesis inhibition Y Quiroz, H Pons, KL Gordon, J Rincón, M Chávez, G Parra, ... American Journal of Physiology-Renal Physiology 281 (1), F38-F47, 2001 | 221 | 2001 |
Activation of NF-κB in tubular epithelial cells of rats with intense proteinuria: role of angiotensin II and endothelin-1 D Gómez-Garre, R Largo, N Tejera, J Fortes, F Manzarbeitia, J Egido Hypertension 37 (4), 1171-1178, 2001 | 217 | 2001 |
Bone mineral measurements of subchondral and trabecular bone in healthy and osteoporotic rabbits S Castaneda, R Largo, E Calvo, F Rodriguez-Salvanes, ME Marcos, ... Skeletal radiology 35, 34-41, 2006 | 205 | 2006 |
Histopathological correlation of cartilage swelling detected by magnetic resonance imaging in early experimental osteoarthritis E Calvo, I Palacios, E Delgado, O Sanchez-Pernaute, R Largo, J Egido, ... Osteoarthritis and cartilage 12 (11), 878-886, 2004 | 169 | 2004 |
ACE inhibition reduces proteinuria, glomerular lesions and extracellular matrix production in a normotensive rat model of immune complex nephritis M Ruiz-Ortega, S González, D Serón, E Condom, C Bustos, R Largo, ... Kidney international 48 (6), 1778-1791, 1995 | 157 | 1995 |
Osteoporosis increases the severity of cartilage damage in an experimental model of osteoarthritis in rabbits E Calvo, S Castaneda, R Largo, ME Fernández-Valle, ... Osteoarthritis and cartilage 15 (1), 69-77, 2007 | 153 | 2007 |
Angiotensin-converting enzyme is upregulated in the proximal tubules of rats with intense proteinuria R Largo, D Gómez-Garre, K Soto, B Marrón, J Blanco, RM Gazapo, ... Hypertension 33 (2), 732-739, 1999 | 149 | 1999 |
Characterization of a new experimental model of osteoporosis in rabbits S Castañeda, E Calvo, R Largo, R González-González, C de la Piedra, ... Journal of bone and mineral metabolism 26, 53-59, 2008 | 146 | 2008 |
Improving subchondral bone integrity reduces progression of cartilage damage in experimental osteoarthritis preceded by osteoporosis M Bellido, L Lugo, JA Roman-Blas, S Castaneda, E Calvo, R Largo, ... Osteoarthritis and cartilage 19 (10), 1228-1236, 2011 | 144 | 2011 |
Long term NSAID treatment inhibits COX-2 synthesis in the knee synovial membrane of patients with osteoarthritis: differential proinflammatory cytokine profile between … MA Álvarez-Soria, R Largo, J Santillana, O Sánchez-Pernaute, E Calvo, ... Annals of the rheumatic diseases 65 (8), 998-1005, 2006 | 143 | 2006 |
Oxidative stress, autophagy, epigenetic changes and regulation by miRNAs as potential therapeutic targets in osteoarthritis S Portal-Nunez, P Esbrit, MJ Alcaraz, R Largo Biochemical pharmacology 108, 1-10, 2016 | 138 | 2016 |
Osteoarthritis: a progressive disease with changing phenotypes S Castañeda, JA Roman-Blas, R Largo, G Herrero-Beaumont Rheumatology 53 (1), 1-3, 2014 | 138 | 2014 |
Combined treatment with chondroitin sulfate and glucosamine sulfate shows no superiority over placebo for reduction of joint pain and functional impairment in patients with … JA Roman‐Blas, S Castañeda, O Sánchez‐Pernaute, R Largo, ... Arthritis & rheumatology 69 (1), 77-85, 2017 | 135 | 2017 |