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Tianle Chen
Tianle Chen
Director, Biostatistics, Biogen, Cambridge, MA
Verified email at biogen.com
Title
Cited by
Cited by
Year
The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease
J Sevigny, P Chiao, T Bussière, PH Weinreb, L Williams, M Maier, ...
Nature 537, 50-56, 2016
32182016
Two randomized phase 3 studies of aducanumab in early Alzheimer’s disease
S Budd Haeberlein, PS Aisen, F Barkhof, S Chalkias, T Chen, S Cohen, ...
The Journal of Prevention of Alzheimer's Disease 9 (2), 197-210, 2022
8932022
Support Vector Hazards Machine: A Counting Process Framework for Learning Risk Scores for Censored Outcomes
Y Wang, T Chen, D Zeng
Journal of Machine Learning Research 17 (167), 1-37, 2016
338*2016
Global gene expression analysis of the shoot apical meristem of maize (Zea mays L.)
K Ohtsu, MB Smith, SJ Emrich, LA Borsuk, R Zhou, T Chen, X Zhang, ...
The Plant Journal 52 (3), 391-404, 2007
1792007
Clinical Development of Aducanumab, an Anti-Aβ Human Monoclonal Antibody Being Investigated for the Treatment of Early Alzheimer's Disease.
HS Budd, J O'Gorman, P Chiao, T Bussière, P von Rosenstiel, Y Tian, ...
The journal of prevention of Alzheimer's disease 4 (4), 255-263, 2017
1392017
Amyloid PET screening for enrichment of early-stage Alzheimer disease clinical trials: experience in a phase 1b clinical trial
J Sevigny, J Suhy, P Chiao, T Chen, G Klein, D Purcell, J Oh, A Verma, ...
Alzheimer Disease & Associated Disorders 30 (1), 1-7, 2016
1242016
Addendum: The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease
J Sevigny, P Chiao, T Bussière, PH Weinreb, L Williams, M Maier, ...
Nature 546 (7659), 564-564, 2017
952017
Impact of Reference and Target Region Selection on Amyloid PET SUV Ratios in the Phase 1b PRIME Study of Aducanumab
P Chiao, BJ Bedell, B Avants, AP Zijdenbos, M Grand'Maison, P O’Neill, ...
Journal of Nuclear Medicine 60 (1), 100-106, 2019
592019
Emerge and Engage topline results: Phase 3 studies of aducanumab in early Alzheimer’s disease: Developments in clinical trials and cognitive assessment
SB Haeberlein, C von Hehn, Y Tian, S Chalkias, KK Muralidharan, ...
Alzheimer's & Dementia 16, e047259, 2020
532020
O4‐04‐05: Aducanumab (BIIB037), an anti‐amyloid beta monoclonal antibody, in patients with prodromal or mild Alzheimer's disease: Interim results of a randomized, double‐blind …
J Sevigny, P Chiao, L Williams, T Chen, Y Ling, J O'Gorman, C Hock, ...
Alzheimer's & Dementia 11 (7S_Part_6), P277-P277, 2015
442015
Pros and cons of prostate cancer screening: Associations with screening knowledge and attitudes among Urban African American men
SN Davis, MA Diefenbach, HB Valdimarsdottir, T Chen, SJ Hall, ...
Journal of the National Medical Association 102 (3), 174-82, 2010
312010
Multiple Kernel Learning with Random Effects for Predicting Longitudinal Outcomes and Data Integration
T Chen, D Zeng, Y Wang
Biometrics 71 (4), 918-928, 2015
262015
Predicting Disease Onset from Mutation Status Using Proband and Relative Data with Applications to Huntington’s Disease
T Chen, Y Wang, Y Ma, K Marder, DR Langbehn
Journal of Probability and Statistics 2012 (doi:10.1155/2012/375935 …, 2012
132012
Targeted Local Support Vector Machine for Age-Dependent Classification
T Chen, Y Wang, H Chen, K Marder, D Zeng
Journal of the American Statistical Association 109 (507), 1174-1187, 2014
102014
Investigating Partially Discordant Results in Phase 3 Studies of Aducanumab
C Mallinckrodt, Y Tian, PS Aisen, F Barkhof, S Cohen, G Dent, O Hansson, ...
The Journal of Prevention of Alzheimer's Disease 10 (2), 171-177, 2023
92023
Aducanumab 36-month data from PRIME: a randomized, double-blind, placebo-controlled Phase 1b study in patients with prodromal or mild Alzheimer’s disease (S2. 004)
SB Haeberlein, S Gheuens, T Chen, J O’Gorman, P von Rosenstiel, ...
Neurology 90 (15 Supplement), 2018
92018
Baseline characteristics from ENGAGE and EMERGE: Two phase 3 studies to evaluate aducanumab in patients with early Alzheimer’s disease (P4. 1-001)
C von Hehn, P von Rosenstiel, Y Tian, S Wu, T Chen, LA Skordos, ...
Neurology 92 (15_supplement), P4. 1-001, 2019
82019
Growth of a Scientific Community of Practice Public Health Services and Systems Research
JA Merrill, JW Keeling, RV Wilson, TV Chen
American Journal of Preventive Medicine 41 (1), 100-104, 2011
82011
O1‐09‐06: 24‐MONTH ANALYSIS OF CHANGE FROM BASELINE IN CLINICAL DEMENTIA RATING SCALE COGNITIVE AND FUNCTIONAL DOMAINS IN PRIME: A RANDOMIZED PHASE 1B STUDY OF THE ANTI–AMYLOID …
SB Haeberlein, C Castrillo-Viguera, S Gheuens, T Chen, J O'Gorman, ...
Alzheimer's & Dementia 14 (7S_Part_4), P242-P242, 2018
62018
CSF biomarker concordance with amyloid PET in Phase 3 studies of aducanumab
L Nisenbaum, R Martone, T Chen, R Rajagovindan, G Dent, J Beaver, ...
Alzheimer's & Dementia, 2023
42023
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