Duxin Sun, PhD
Duxin Sun, PhD
Associate Dean for Research and the Charles Walgreen Jr. Professor at the College of Pharmacy, UM
Verified email at - Homepage
Cited by
Cited by
Engineering exosomes as refined biological nanoplatforms for drug delivery
X Luan, K Sansanaphongpricha, I Myers, H Chen, H Yuan, D Sun
Acta Pharmacologica Sinica 38 (6), 754-763, 2017
Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells
Y Li, T Zhang, H Korkaya, S Liu, HF Lee, B Newman, Y Yu, SG Clouthier, ...
Clinical Cancer Research 16 (9), 2580-2590, 2010
Why 90% of clinical drug development fails and how to improve it?
D Sun, W Gao, H Hu, S Zhou
Acta Pharmaceutica Sinica B 12 (7), 3049-3062, 2022
Comparison of human duodenum and Caco-2 gene expression profiles for 12,000 gene sequences tags and correlation with permeability of 26 drugs
D Sun, H Lennernas, LS Welage, JL Barnett, CP Landowski, D Foster, ...
Pharmaceutical research 19, 1400-1416, 2002
Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model
X Cao, ST Gibbs, L Fang, HA Miller, CP Landowski, HC Shin, ...
Pharmaceutical research 23, 1675-1686, 2006
A potent and selective small-molecule degrader of STAT3 achieves complete tumor regression in vivo
L Bai, H Zhou, R Xu, Y Zhao, K Chinnaswamy, D McEachern, J Chen, ...
Cancer cell 36 (5), 498-511. e17, 2019
A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells
T Zhang, A Hamza, X Cao, B Wang, S Yu, CG Zhan, D Sun
Molecular cancer therapeutics 7 (1), 162-170, 2008
Discovery of a small-molecule degrader of bromodomain and extra-terminal (BET) proteins with picomolar cellular potencies and capable of achieving tumor regression
B Zhou, J Hu, F Xu, Z Chen, L Bai, E Fernandez-Salas, M Lin, L Liu, ...
Journal of medicinal chemistry 61 (2), 462-481, 2018
Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo
D Borkin, S He, H Miao, K Kempinska, J Pollock, J Chase, T Purohit, ...
Cancer cell 27 (4), 589-602, 2015
Withaferin A targets heat shock protein 90 in pancreatic cancer cells
Y Yu, A Hamza, T Zhang, M Gu, P Zou, B Newman, Y Li, AAL Gunatilaka, ...
Biochemical pharmacology 79 (4), 542-551, 2010
Aerobic glycolysis controls myeloid-derived suppressor cells and tumor immunity via a specific CEBPB isoform in triple-negative breast cancer
W Li, T Tanikawa, I Kryczek, H Xia, G Li, KE Wu, S Wei, L Zhao, L Vatan, ...
Cell metabolism 28 (1), 87-103. e6, 2018
Disruption of 12/15-lipoxygenase expression in peritoneal macrophages: enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein
D Sun, CD Funk
Journal of Biological Chemistry 271 (39), 24055-24062, 1996
A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment
Q Cai, H Sun, Y Peng, J Lu, Z Nikolovska-Coleska, D McEachern, L Liu, ...
Journal of medicinal chemistry 54 (8), 2714-2726, 2011
A potent small-molecule inhibitor of the MDM2–p53 interaction (MI-888) achieved complete and durable tumor regression in mice
Y Zhao, S Yu, W Sun, L Liu, J Lu, D McEachern, S Shargary, D Bernard, ...
Journal of medicinal chemistry 56 (13), 5553-5561, 2013
Glucose uptake inhibitor sensitizes cancer cells to daunorubicin and overcomes drug resistance in hypoxia
X Cao, L Fang, S Gibbs, Y Huang, Z Dai, P Wen, X Zheng, W Sadee, ...
Cancer chemotherapy and pharmacology 59, 495-505, 2007
Discovery of QCA570 as an exceptionally potent and efficacious proteolysis targeting chimera (PROTAC) degrader of the bromodomain and extra-terminal (BET) proteins capable of …
C Qin, Y Hu, B Zhou, E Fernandez-Salas, CY Yang, L Liu, D McEachern, ...
Journal of medicinal chemistry 61 (15), 6685-6704, 2018
New developments in Hsp90 inhibitors as anti-cancer therapeutics: mechanisms, clinical perspective and more potential
Y Li, T Zhang, SJ Schwartz, D Sun
Drug Resistance Updates 12 (1-2), 17-27, 2009
Diastereomeric spirooxindoles as highly potent and efficacious MDM2 inhibitors
Y Zhao, L Liu, W Sun, J Lu, D McEachern, X Li, S Yu, D Bernard, ...
Journal of the American Chemical Society 135 (19), 7223-7234, 2013
Implications of cancer stem cell theory for cancer chemoprevention by natural dietary compounds
Y Li, MS Wicha, SJ Schwartz, D Sun
The Journal of nutritional biochemistry 22 (9), 799-806, 2011
Biodegradable self-assembled nanoparticles of poly (D, L-lactide-co-glycolide)/hyaluronic acid block copolymers for target delivery of docetaxel to breast cancer
J Huang, H Zhang, Y Yu, Y Chen, D Wang, G Zhang, G Zhou, J Liu, Z Sun, ...
Biomaterials 35 (1), 550-566, 2014
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