| Construction of 3D-QSAR models using the 4D-QSAR analysis formalism AJ Hopfinger, S Wang, JS Tokarski, B Jin, M Albuquerque, PJ Madhav, ... Journal of the American Chemical Society 119 (43), 10509-10524, 1997 | 553 | 1997 |
| Autolytic proteolysis within the function to find domain (FIIND) is required for NLRP1 inflammasome activity JN Finger, JD Lich, LC Dare, MN Cook, KK Brown, C Duraiswami, ... Journal of Biological Chemistry 287 (30), 25030-25037, 2012 | 279 | 2012 |
| New IDH1 mutant inhibitors for treatment of acute myeloid leukemia UC Okoye-Okafor, B Bartholdy, J Cartier, EN Gao, B Pietrak, AR Rendina, ... Nature chemical biology 11 (11), 878-886, 2015 | 187 | 2015 |
| A tale of two subunits: how the neomorphic R132H IDH1 mutation enhances production of αHG B Pietrak, H Zhao, H Qi, C Quinn, E Gao, JG Boyer, N Concha, K Brown, ... Biochemistry 50 (21), 4804-4812, 2011 | 121 | 2011 |
| Mutant IDH1 enhances the production of 2-hydroxyglutarate due to its kinetic mechanism AR Rendina, B Pietrak, A Smallwood, H Zhao, H Qi, C Quinn, ND Adams, ... Biochemistry 52 (26), 4563-4577, 2013 | 83 | 2013 |
| Use of catalyst pharmacophore models for screening of large combinatorial libraries EA Hecker, C Duraiswami, TA Andrea, DJ Diller Journal of chemical information and computer sciences 42 (5), 1204-1211, 2002 | 80 | 2002 |
| Solution of the conformation and alignment tensors for the binding of trimethoprim and its analogs to dihydrofolate reductase: 3D-quantitative structure− activity relationship … WJ Dunn, AJ Hopfinger, C Catana, C Duraiswami Journal of medicinal chemistry 39 (24), 4825-4832, 1996 | 39 | 1996 |
| 2-Amino-9-aryl-3-cyano-4-methyl-7-oxo-6, 7, 8, 9-tetrahydropyrido [2′, 3′: 4, 5] thieno [2, 3-b] pyridine derivatives as selective progesterone receptor agonists Y Wang, C Duraiswami, KP Madauss, TB Tran, SP Williams, SJ Deng, ... Bioorganic & medicinal chemistry letters 19 (17), 4916-4919, 2009 | 22 | 2009 |
| Synthesis and SAR of potent LXR agonists containing an indole pharmacophore DG Washburn, TH Hoang, N Campobasso, A Smallwood, DJ Parks, ... Bioorganic & medicinal chemistry letters 19 (4), 1097-1100, 2009 | 22 | 2009 |
| Rational design of orally-active, pyrrolidine-based progesterone receptor partial agonists SK Thompson, DG Washburn, JS Frazee, KP Madauss, TH Hoang, ... Bioorganic & medicinal chemistry letters 19 (16), 4777-4780, 2009 | 21 | 2009 |
| High throughput screening identifies ATP-competitive inhibitors of the NLRP1 inflammasome PA Harris, C Duraiswami, DT Fisher, J Fornwald, SJ Hoffman, G Hofmann, ... Bioorganic & Medicinal Chemistry Letters 25 (14), 2739-2743, 2015 | 18 | 2015 |
| Discovery of orally active, pyrrolidinone-based progesterone receptor partial agonists DG Washburn, TH Hoang, JS Frazee, L Johnson, M Hammond, S Manns, ... Bioorganic & medicinal chemistry letters 19 (16), 4664-4668, 2009 | 15 | 2009 |
| Improving the developability profile of pyrrolidine progesterone receptor partial agonists LS Kallander, DG Washburn, TH Hoang, JS Frazee, P Stoy, L Johnson, ... Bioorganic & medicinal chemistry letters 20 (1), 371-374, 2010 | 13 | 2010 |
| Discovery and electrophysiological characterization of SKF-32802: a novel hERG agonist found through a large-scale structural similarity search BT Donovan, D Bandyopadhyay, C Duraiswami, CJ Nixon, CY Townsend, ... European Journal of Pharmacology 818, 306-327, 2018 | 11 | 2018 |
| Understanding the origins of time-dependent inhibition by polypeptide deformylase inhibitors R Totoritis, C Duraiswami, AN Taylor, JJ Kerrigan, N Campobasso, ... Biochemistry 50 (31), 6642-6654, 2011 | 5 | 2011 |
| Correction to identification of quinoline-based RIP2 kinase inhibitors with an improved therapeutic index to the hERG ion channel PA Haile, LN Casillas, MJ Bury, JF Mehlmann, R Singhaus Jr, ... ACS Medicinal Chemistry Letters 11 (6), 1353-1353, 2020 | 3 | 2020 |
| New allosteric inhibitors of mutant IDH1 in acute myeloid leukemia UC Okoye-Okafor, B Bartholdy, J Cartier, E Gao, B Pietrak, AR Rendina, ... Blood, The Journal of the American Society of Hematology 126 (23), 787-787, 2015 | 2 | 2015 |
| Peptide deformylase inhibitors KM Aubart, SB Christensen IV, C Duraiswami, JM Karpinski US Patent 7,332,485, 2008 | 2 | 2008 |
| De novo design of novel polypeptide deformylase (PDF) inhibitor templates with broad spectrum antibacterial activity C Duraiswami, RA Daines, N Campobasso, M Vimal, I Pendrak, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 238, 2009 | 1 | 2009 |
| Application of 4D-QSAR Analysis to a Set of Prostaglandin, PGF2α, Analogs C Duraiswami, PJ Madhav, AJ Hopfinger Molecular Modeling and Prediction of Bioactivity, 323-324, 2000 | 1 | 2000 |
Kevin MadaussGlaxoSmithKlineVerified email at gsk.com
