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Manu Vanaerschot
Manu Vanaerschot
Roche Diagnostics, Infectious Diseases
Verified email at roche.com
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Year
Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance
T Downing, H Imamura, S Decuypere, TG Clark, GH Coombs, JA Cotton, ...
Genome research 21 (12), 2143-2156, 2011
4382011
Increasing failure of miltefosine in the treatment of Kala-azar in Nepal and the potential role of parasite drug resistance, reinfection, or noncompliance
S Rijal, B Ostyn, S Uranw, K Rai, NR Bhattarai, TPC Dorlo, JH Beijnen, ...
Clinical Infectious Diseases 56 (11), 1530-1538, 2013
3182013
Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics
AN Cowell, ES Istvan, AK Lukens, MG Gomez-Lorenzo, M Vanaerschot, ...
Science 359 (6372), 191-199, 2018
1672018
Evolutionary genomics of epidemic visceral leishmaniasis in the Indian subcontinent
H Imamura, T Downing, F Van den Broeck, MJ Sanders, S Rijal, S Sundar, ...
Elife 5, e12613, 2016
1372016
Modulation of Aneuploidy in Leishmania donovani during Adaptation to Different In Vitro and In Vivo Environments and Its Impact on Gene Expression
F Dumetz, H Imamura, M Sanders, V Seblova, J Myskova, P Pescher, ...
MBio 8 (3), e00599-17, 2017
1342017
Evaluation of normalization methods to pave the way towards large-scale LC-MS-based metabolomics profiling experiments
BA Ejigu, D Valkenborg, G Baggerman, M Vanaerschot, E Witters, ...
Omics: a journal of integrative biology 17 (9), 473-485, 2013
1052013
Molecular Mechanisms of Drug Resistance in Natural Leishmania Populations Vary with Genetic Background
S Decuypere, M Vanaerschot, K Brunker, H Imamura, S Müller, B Khanal, ...
PLoS neglected tropical diseases 6 (2), e1514, 2012
922012
Open-source discovery of chemical leads for next-generation chemoprotective antimalarials
Y Antonova-Koch, S Meister, M Abraham, MR Luth, S Ottilie, AK Lukens, ...
Science 362 (6419), eaat9446, 2018
812018
Treatment failure in leishmaniasis: drug-resistance or another (epi-) phenotype?
M Vanaerschot, F Dumetz, S Roy, A Ponte-Sucre, J Arevalo, JC Dujardin
Expert review of anti-infective therapy 12 (8), 937-946, 2014
732014
Relapse after treatment with miltefosine for visceral leishmaniasis is associated with increased infectivity of the infecting Leishmania donovani strain
K Rai, B Cuypers, NR Bhattarai, S Uranw, M Berg, B Ostyn, JC Dujardin, ...
MBio 4 (5), e00611-13, 2013
732013
Linking in vitro and in vivo survival of clinical Leishmania donovani strains
M Vanaerschot, I Maes, M Ouakad, V Adaui, L Maes, S De Doncker, ...
PLoS One 5 (8), e12211, 2010
732010
Antileishmanial Activity of a Series of N2,N4-Disubstituted Quinazoline-2,4-diamines
KS Van Horn, X Zhu, T Pandharkar, S Yang, B Vesely, M Vanaerschot, ...
Journal of medicinal chemistry 57 (12), 5141-5156, 2014
692014
Detection of Leptomonas sp. parasites in clinical isolates of Kala-azar patients from India
P Srivastava, VK Prajapati, M Vanaerschot, G Van der Auwera, ...
Infection, Genetics and Evolution 10 (7), 1145-1150, 2010
662010
Treatment of Visceral Leishmaniasis: Model-Based Analyses on the Spread of Antimony-Resistant L. donovani in Bihar, India
A Stauch, HP Duerr, JC Dujardin, M Vanaerschot, S Sundar, M Eichner
PLoS neglected tropical diseases 6 (12), e1973, 2012
582012
Genome-wide SNP and microsatellite variation illuminate population-level epidemiology in the Leishmania donovani species complex
T Downing, O Stark, M Vanaerschot, H Imamura, M Sanders, ...
Infection, Genetics and Evolution 12 (1), 149-159, 2012
582012
LC-MS metabolomics from study design to data-analysis–using a versatile pathogen as a test case
M Berg, M Vanaerschot, A Jankevics, B Cuypers, R Breitling, JC Dujardin
Computational and structural biotechnology journal 4 (5), e201301002, 2013
572013
Antimonial resistance in Leishmania donovani is associated with increased in vivo parasite burden
M Vanaerschot, S De Doncker, S Rijal, L Maes, JC Dujardin, S Decuypere
PloS one 6 (8), e23120, 2011
572011
Metabolic adaptations of Leishmania donovani in relation to differentiation, drug resistance, and drug pressure
M Berg, M Vanaerschot, A Jankevics, B Cuypers, I Maes, S Mukherjee, ...
Molecular microbiology 90 (2), 428-442, 2013
562013
Drug resistance in vectorborne parasites: multiple actors and scenarios for an evolutionary arms race
M Vanaerschot, S Huijben, F Van den Broeck, JC Dujardin
FEMS microbiology reviews 38 (1), 41-55, 2014
552014
Increased metacyclogenesis of antimony-resistant Leishmania donovani clinical lines
M Ouakad, M Vanaerschot, S Rijal, S Sundar, N Speybroeck, L Kestens, ...
Parasitology 138 (11), 1392-1399, 2011
532011
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