Clemens Lowik
Clemens Lowik
Professor Optical Molecular Imaging, Dept Radiology, Erasmus Medical Center, Rotterdam
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Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation
KES Poole, RL Van Bezooijen, N Loveridge, H Hamersma, ...
The FASEB journal 19 (13), 1842-1844, 2005
Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist
RL Van Bezooijen, BAJ Roelen, A Visser, L Van Der Wee-pals, E De Wilt, ...
The Journal of experimental medicine 199 (6), 805-814, 2004
Bone morphogenetic proteins stimulate angiogenesis through osteoblast-derived vascular endothelial growth factor A
MML Deckers, RL Van Bezooijen, G Van Der Horst, J Hoogendam, ...
Endocrinology 143 (4), 1545-1553, 2002
The clinical use of indocyanine green as a near‐infrared fluorescent contrast agent for image‐guided oncologic surgery
BE Schaafsma, JSD Mieog, M Hutteman, JR Van der Vorst, PJK Kuppen, ...
Journal of surgical oncology 104 (3), 323-332, 2011
Expression of vascular endothelial growth factors and their receptors during osteoblast differentiation
MML Deckers, M Karperien, C van der Bent, T Yamashita, SE Papapoulos, ...
Endocrinology 141 (5), 1667-1674, 2000
Mesenchymal stem cells promote engraftment of human umbilical cord blood–derived CD34+ cells in NOD/SCID mice
WA Noort, AB Kruisselbrink, PS in't Anker, M Kruger, RL van Bezooijen, ...
Experimental hematology 30 (8), 870-878, 2002
Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates
E van Beek, E Pieterman, L Cohen, C Löwik, S Papapoulos
Biochemical and biophysical research communications 264 (1), 108-111, 1999
BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis
M Scharpfenecker, M van Dinther, Z Liu, RL van Bezooijen, Q Zhao, ...
Journal of cell science 120 (6), 964-972, 2007
Endostatin inhibits VEGF-induced endothelial cell migration and tumor growth independently of zinc binding
N Yamaguchi, B Anand-Apte, M Lee, T Sasaki, N Fukai, R Shapiro, I Que, ...
The EMBO journal 18 (16), 4414-4423, 1999
The tumor suppressor Smad4 is required for transforming growth factor β–induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells
M Deckers, M van Dinther, J Buijs, I Que, C Lowik, G van der Pluijm, ...
Cancer research 66 (4), 2202-2209, 2006
Peroxisome proliferator-activated receptor γ (PPARγ) as a molecular target for the soy phytoestrogen genistein
ZC Dang, V Audinot, SE Papapoulos, JA Boutin, CWGM Löwik
Journal of Biological Chemistry 278 (2), 962-967, 2003
SOST/sclerostin, an osteocyte-derived negative regulator of bone formation
RL van Bezooijen, P ten Dijke, SE Papapoulos, CWGM Löwik
Cytokine & growth factor reviews 16 (3), 319-327, 2005
Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP‐stimulated bone formation
RL Van Bezooijen, JP Svensson, D Eefting, A Visser, G van der Horst, ...
Journal of Bone and Mineral Research 22 (1), 19-28, 2007
Differential expression of estrogen receptors α and β mRNA during differentiation of human osteoblast SV-HFO cells
J Arts, GGJM Kuiper, JMMF Janssen, JA Gustafsson, CWGM Löwik, ...
Endocrinology 138 (11), 5067-5070, 1997
Bisphosphonates inhibit the adhesion of breast cancer cells to bone matrices in vitro.
G van der Pluijm, H Vloedgraven, E van Beek, L van der Wee-Pals, ...
The Journal of clinical investigation 98 (3), 698-705, 1996
In vivo imaging of transcriptionally active estrogen receptors
P Ciana, M Raviscioni, P Mussi, E Vegeto, I Que, MG Parker, C Lowik, ...
Nature medicine 9 (1), 82-86, 2003
Optical image-guided surgery—where do we stand?
S Keereweer, JDF Kerrebijn, PBAA Van Driel, B Xie, EL Kaijzel, ...
Molecular Imaging and Biology 13, 199-207, 2011
Murine malaria parasite sequestration: CD36 is the major receptor, but cerebral pathology is unlinked to sequestration
B Franke-Fayard, CJ Janse, M Cunha-Rodrigues, J Ramesar, P Büscher, ...
Proceedings of the National Academy of Sciences 102 (32), 11468-11473, 2005
The role of geranylgeranylation in bone resorption and its suppression by bisphosphonates in fetal bone explants in vitro: a clue to the mechanism of action of nitrogen …
E Van Beek, C Löwik, G Van Der Pluijm, S Papapoulos
Journal of Bone and Mineral Research 14 (5), 722-729, 1999
Near‐infrared fluorescence‐guided resection of colorectal liver metastases
JR van der Vorst, BE Schaafsma, M Hutteman, FPR Verbeek, GJ Liefers, ...
Cancer 119 (18), 3411-3418, 2013
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