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Simon A Cobbold
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Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome
JL Bridgford, SC Xie, SA Cobbold, CFA Pasaje, S Herrmann, T Yang, ...
Nature communications 9 (1), 1-9, 2018
1842018
Plasmodium falciparum responds to amino acid starvation by entering into a hibernatory state
SE Babbitt, L Altenhofen, SA Cobbold, ES Istvan, C Fennell, C Doerig, ...
Proceedings of the National Academy of Sciences 109 (47), E3278-E3287, 2012
1492012
Metabolic QTL Analysis Links Chloroquine Resistance in Plasmodium falciparum to Impaired Hemoglobin Catabolism
IA Lewis, M Wacker, KL Olszewski, SA Cobbold, KS Baska, A Tan, ...
PLoS genetics 10 (1), e1004085, 2014
1032014
Decreased K13 abundance reduces hemoglobin catabolism and proteotoxic stress, underpinning artemisinin resistance
T Yang, LM Yeoh, MV Tutor, MW Dixon, PJ McMillan, SC Xie, JL Bridgford, ...
Cell Reports 29 (9), 2917-2928. e5, 2019
842019
Metabolomics-based screening of the malaria box reveals both novel and established mechanisms of action
DJ Creek, HH Chua, SA Cobbold, B Nijagal, JI MacRae, BK Dickerman, ...
Antimicrobial agents and chemotherapy 60 (11), 6650-6663, 2016
822016
Kinetic flux profiling elucidates two independent acetyl-CoA biosynthetic pathways in Plasmodium falciparum
SA Cobbold, AM Vaughan, IA Lewis, HJ Painter, N Camargo, DH Perlman, ...
Journal of Biological Chemistry 288 (51), 36338-36350, 2013
822013
Proteome-wide analysis reveals widespread lysine acetylation of major protein complexes in the malaria parasite
SA Cobbold, JM Santos, A Ochoa, DH Perlman, M Llinás
Scientific reports 6 (1), 1-14, 2016
762016
Metabolic Dysregulation Induced in Plasmodium falciparum by Dihydroartemisinin and Other Front-Line Antimalarial Drugs
SA Cobbold, HH Chua, B Nijagal, DJ Creek, SA Ralph, MJ McConville
The Journal of infectious diseases 213 (2), 276-286, 2016
632016
The Plasmodium falciparum transcriptome in severe malaria reveals altered expression of genes involved in important processes including surface antigen–encoding var genes
GQ Tonkin-Hill, L Trianty, R Noviyanti, HHT Nguyen, BF Sebayang, ...
PLoS biology 16 (3), e2004328, 2018
562018
Targeting NAD+ metabolism in the human malaria parasite Plasmodium falciparum
JK O'Hara, LJ Kerwin, SA Cobbold, J Tai, TA Bedell, PJ Reider, M Llinás
PLoS One 9 (4), e94061, 2014
502014
Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking
K Kennedy, SA Cobbold, E Hanssen, J Birnbaum, NJ Spillman, ...
PLoS Biology 17 (7), e3000376, 2019
492019
The natural function of the malaria parasite’s chloroquine resistance transporter
SH Shafik, SA Cobbold, K Barkat, SN Richards, NS Lancaster, M Llinás, ...
Nature communications 11 (1), 1-16, 2020
432020
Identification of inhibitors that dually target the new permeability pathway and dihydroorotate dehydrogenase in the blood stage of Plasmodium falciparum
BK Dickerman, B Elsworth, SA Cobbold, CQ Nie, MJ McConville, ...
Scientific Reports 6 (1), 1-15, 2016
422016
Methionine transport in the malaria parasite Plasmodium falciparum
SA Cobbold, RE Martin, K Kirk
International journal for parasitology 41 (1), 125-135, 2011
412011
The malaria parasite's lactate transporter PfFNT is the target of antiplasmodial compounds identified in whole cell phenotypic screens
SV Hapuarachchi, SA Cobbold, SH Shafik, ASM Dennis, MJ McConville, ...
PLoS pathogens 13 (2), e1006180, 2017
392017
Using metabolomics to dissect host–parasite interactions
J Kloehn, M Blume, SA Cobbold, EC Saunders, MJ Dagley, ...
Current opinion in microbiology 32, 59-65, 2016
392016
A family of dual-activity glycosyltransferase-phosphorylases mediates mannogen turnover and virulence in Leishmania parasites
MF Sernee, JE Ralton, TL Nero, LF Sobala, J Kloehn, MA Vieira-Lara, ...
Cell host & microbe 26 (3), 385-399. e9, 2019
322019
Sequestration and metabolism of host cell arginine by the intraerythrocytic malaria parasite Plasmodium falciparum
SA Cobbold, M Llinás, K Kirk
Cellular microbiology 18 (6), 820-830, 2016
292016
The metabolite repair enzyme Phosphoglycolate phosphatase regulates central carbon metabolism and fosmidomycin sensitivity in plasmodium falciparum
L Dumont, MB Richardson, P van der Peet, DS Marapana, T Triglia, ...
MBio 10 (6), e02060-19, 2019
182019
A high parasite density environment induces transcriptional changes and cell death in Plasmodium falciparum blood stages
ES Chou, SZ Abidi, M Teye, A Leliwa‐Sytek, TS Rask, SA Cobbold, ...
The FEBS journal 285 (5), 848-870, 2018
172018
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