| On the rate and extent of drug delivery to the brain M Hammarlund-Udenaes, M Fridén, S Syvänen, A Gupta Pharmaceutical research 25, 1737-1750, 2008 | 552 | 2008 |
| Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport S Syvänen, Ö Lindhe, M Palner, BR Kornum, O Rahman, B Långström, ... Drug metabolism and disposition 37 (3), 635-643, 2009 | 401 | 2009 |
| Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer’s disease D Sehlin, XT Fang, L Cato, G Antoni, L Lannfelt, S Syvänen Nature communications 7 (1), 10759, 2016 | 209 | 2016 |
| Bivalent brain shuttle increases antibody uptake by monovalent binding to the transferrin receptor G Hultqvist, S Syvänen, XT Fang, L Lannfelt, D Sehlin Theranostics 7 (2), 308, 2017 | 184 | 2017 |
| Advances in the development of new biomarkers for Alzheimer’s disease TO Klyucherev, P Olszewski, AA Shalimova, VN Chubarev, VV Tarasov, ... Translational neurodegeneration 11 (1), 25, 2022 | 160 | 2022 |
| Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells XT Fang, D Sehlin, L Lannfelt, S Syvänen, G Hultqvist Biological procedures online 19, 1-9, 2017 | 102 | 2017 |
| Advances in PET imaging of P-glycoprotein function at the blood-brain barrier S Syvänen, J Eriksson ACS chemical neuroscience 4 (2), 225-237, 2013 | 92 | 2013 |
| Specific uptake of an amyloid-β protofibril-binding antibody-tracer in AβPP transgenic mouse brain K Magnusson, D Sehlin, S Syvänen, MM Svedberg, O Philipson, ... Journal of Alzheimer's Disease 37 (1), 29-40, 2013 | 92 | 2013 |
| Delineating amyloid plaque associated neuronal sphingolipids in transgenic Alzheimer’s disease mice (tgArcSwe) using MALDI imaging mass spectrometry I Kaya, D Brinet, W Michno, S Syvänen, D Sehlin, H Zetterberg, ... ACS chemical neuroscience 8 (2), 347-355, 2017 | 88 | 2017 |
| Astroglial responses to amyloid-beta progression in a mouse model of Alzheimer’s disease M Olsen, X Aguilar, D Sehlin, XT Fang, G Antoni, A Erlandsson, ... Molecular Imaging and Biology 20, 605-614, 2018 | 81 | 2018 |
| Engineered antibodies: new possibilities for brain PET? D Sehlin, S Syvänen European journal of nuclear medicine and molecular imaging 46 (13), 2848-2858, 2019 | 77 | 2019 |
| Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1–40 deposition underlies plaque polymorphism in progressing Alzheimer’s disease pathology W Michno, S Nyström, P Wehrli, T Lashley, G Brinkmalm, L Guerard, ... Journal of Biological Chemistry 294 (17), 6719-6732, 2019 | 77 | 2019 |
| Duration and degree of cyclosporin induced P-glycoprotein inhibition in the rat blood–brain barrier can be studied with PET S Syvänen, G Blomquist, M Sprycha, AU Höglund, M Roman, O Eriksson, ... Neuroimage 32 (3), 1134-1141, 2006 | 76 | 2006 |
| Pharmacokinetic consequences of active drug efflux at the blood–brain barrier S Syvänen, R Xie, S Sahin, M Hammarlund-Udenaes Pharmaceutical research 23, 705-717, 2006 | 75 | 2006 |
| Efficient clearance of Aβ protofibrils in AβPP-transgenic mice treated with a brain-penetrating bifunctional antibody S Syvänen, G Hultqvist, T Gustavsson, A Gumucio, H Laudon, ... Alzheimer's Research & Therapy 10, 1-10, 2018 | 73 | 2018 |
| High detection sensitivity with antibody-based PET radioligand for amyloid beta in brain XT Fang, G Hultqvist, SR Meier, G Antoni, D Sehlin, S Syvänen Neuroimage 184, 881-888, 2019 | 69 | 2019 |
| A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils–a new concept for neuroimaging S Syvänen, XT Fang, G Hultqvist, SR Meier, L Lannfelt, D Sehlin Neuroimage 148, 55-63, 2017 | 64 | 2017 |
| Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size R Faresjö, G Bonvicini, XT Fang, X Aguilar, D Sehlin, S Syvänen Fluids and Barriers of the CNS 18 (1), 26, 2021 | 59 | 2021 |
| Probing amyloid‐β pathology in transgenic Alzheimer's disease (tgArcSwe) mice using MALDI imaging mass spectrometry L Carlred, W Michno, I Kaya, P Sjövall, S Syvänen, J Hanrieder Journal of neurochemistry 138 (3), 469-478, 2016 | 58 | 2016 |
| SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-β antibody in a mouse model of Alzheimer’s disease T Gustavsson, S Syvänen, P O’Callaghan, D Sehlin Translational Neurodegeneration 9 (1), 37, 2020 | 56 | 2020 |
Dag SehlinAssociate professor, Uppsala universityVerified email at pubcare.uu.se
