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Georg Wuitschik
Georg Wuitschik
Senior Scientist, Roche
Dirección de correo verificada de roche.com
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Oxetanes as versatile elements in drug discovery and synthesis
JA Burkhard, G Wuitschik, M Rogers‐Evans, K Müller, EM Carreira
Angewandte Chemie International Edition 49 (48), 9052-9067, 2010
4122010
Oxetanes in drug discovery: structural and synthetic insights
G Wuitschik, EM Carreira, B Wagner, H Fischer, I Parrilla, F Schuler, ...
Journal of medicinal chemistry 53 (8), 3227-3246, 2010
3842010
Oxetanes as promising modules in drug discovery
G Wuitschik, M Rogers‐Evans, K Müller, H Fischer, B Wagner, F Schuler, ...
Angewandte Chemie International Edition 45 (46), 7736-7739, 2006
2582006
Spirocyclic oxetanes: synthesis and properties
G Wuitschik, M Rogers-Evans, A Buckl, M Bernasconi, M Marki, T Godel, ...
Angewandte Chemie 120 (24), 4588, 2008
2202008
Piperazic acid-containing natural products: isolation, biological relevance and total synthesis
AJ Oelke, DJ France, T Hofmann, G Wuitschik, SV Ley
Natural Product Reports 28 (8), 1445-1471, 2011
902011
Synthesis and stability of oxetane analogs of thalidomide and lenalidomide
JA Burkhard, G Wuitschik, JM Plancher, M Rogers-Evans, EM Carreira
Organic letters 15 (17), 4312-4315, 2013
872013
Oxetane als vielseitige Bausteine in der Wirkstoff‐Forschung und Synthese
JA Burkhard, G Wuitschik, M Rogers‐Evans, K Müller, EM Carreira
Angewandte Chemie 122 (48), 9236-9251, 2010
852010
A Ru-Catalyzed Tandem Alkyne−Enone Coupling/Michael Addition:  Synthesis of 4-Methylene-2,6-cis-tetrahydropyrans
BM Trost, H Yang, G Wuitschik
Organic Letters 7 (21), 4761-4764, 2005
702005
Total synthesis of chloptosin
AJ Oelke, DJ France, T Hofmann, G Wuitschik, SV Ley
Angewandte Chemie International Edition 49 (35), 6139-6142, 2010
562010
Total synthesis of chloptosin: A dimeric cyclohexapeptide
AJ Oelke, F Antonietti, L Bertone, PB Cranwell, DJ France, RJM Goss, ...
Chemistry–A European Journal 17 (15), 4183-4194, 2011
502011
What can reaction databases teach us about Buchwald–Hartwig cross-couplings?
M Fitzner, G Wuitschik, RJ Koller, JM Adam, T Schindler, JL Reymond
Chemical science 11 (48), 13085-13093, 2020
462020
A Robust, Recyclable Resin for Decagram Scale Resolution of (±)‐Mefloquine and Other Chiral N‐Heterocycles
I Kreituss, KY Chen, SH Eitel, JM Adam, G Wuitschik, A Fettes, JW Bode
Angewandte Chemie International Edition 55 (4), 1553-1556, 2016
242016
Using data analysis to evaluate and compare chemical syntheses
D Kaiser, J Yang, G Wuitschik
Organic Process Research & Development 22 (9), 1222-1235, 2018
232018
The search for tricyanomethane (cyanoform)
D Šišak, LB McCusker, A Buckl, G Wuitschik, YL Wu, WB Schweizer, ...
Chemistry–A European Journal 16 (24), 7224-7230, 2010
222010
Enabling late-stage drug diversification by high-throughput experimentation with geometric deep learning
DF Nippa, K Atz, R Hohler, AT Müller, A Marx, C Bartelmus, G Wuitschik, ...
Nature Chemistry 16 (2), 239-248, 2024
172024
Machine Learning C–N Couplings: Obstacles for a General-Purpose Reaction Yield Prediction
M Fitzner, G Wuitschik, R Koller, JM Adam, T Schindler
ACS omega 8 (3), 3017-3025, 2023
162023
Oxetanes in drug discovery
G Wuitschik
ETH Zurich, 2008
152008
Tricyanomethane and its salts with nitrogen bases: A correction of sixteen reports
K Banert, M Hagedorn
Synlett 30 (12), 1427-1430, 2019
142019
Accounting for different reactivities of sulfinate and thiosulfate salts in regioselective azetidine coupling via C–H sulfenylation of indoles
MAE Al-Saedy, ACMA Nassoy, JPA Harrity
Synlett 29 (03), 349-353, 2018
72018
Oxetan‐3‐one: Chemistry and Synthesis
G Wuitschik, EM Carreira, M Rogers‐Evans, K Muller
ChemInform 40 (13), no-no, 2009
72009
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Artículos 1–20