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Sarah Grimwood
Sarah Grimwood
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Title
Cited by
Cited by
Year
4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationships for antagonism at the glycine site of the NMDA receptor
PD Leeson, RW Carling, KW Moore, AM Moseley, JD Smith, G Stevenson, ...
Journal of medicinal chemistry 35 (11), 1954-1968, 2002
2602002
Design and selection parameters to accelerate the discovery of novel central nervous system positron emission tomography (PET) ligands and their application in the development …
L Zhang, A Villalobos, EM Beck, T Bocan, TA Chappie, L Chen, ...
Journal of medicinal chemistry 56 (11), 4568-4579, 2013
1782013
Identification of molecular determinants that are important in the assembly of N-methyl-D-aspartate receptors
E Meddows, B Le Bourdelles, S Grimwood, K Wafford, S Sandhu, ...
Journal of Biological Chemistry 276 (22), 18795-18803, 2001
1732001
Effect of plasma protein binding on in vivo activity and brain penetration of glycine/NMDA receptor antagonists
M Rowley, JJ Kulagowski, AP Watt, D Rathbone, GI Stevenson, ...
Journal of medicinal chemistry 40 (25), 4053-4068, 1997
1711997
2-Carboxytetrahydroquinolines. Conformational and stereochemical requirements for antagonism of the glycine site on the N-methyl-D-aspartate (NMDA) receptor
RW Carling, PD Leeson, AM Moseley, R Baker, AC Foster, S Grimwood, ...
Journal of medicinal chemistry 35 (11), 1942-1953, 1992
1341992
Target site occupancy: emerging generalizations from clinical and preclinical studies
S Grimwood, PR Hartig
Pharmacology & therapeutics 122 (3), 281-301, 2009
1322009
Duration of action of a broad range of selective κ-opioid receptor antagonists is positively correlated with c-Jun N-terminal kinase-1 activation
EJ Melief, M Miyatake, FI Carroll, C Beguin, WA Carlezon, BM Cohen, ...
Molecular pharmacology 80 (5), 920-929, 2011
1302011
3-Nitro-3, 4-dihydro-2 (1H)-quinolones. Excitatory amino acid antagonists acting at glycine-site NMDA and (RS)-. alpha.-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors
RW Carling, PD Leeson, KW Moore, JD Smith, CR Moyes, IM Mawer, ...
Journal of medicinal chemistry 36 (22), 3397-3408, 1993
1221993
NR2B-containing NMDA receptors are up-regulated in temporal cortex in schizophrenia
S Grimwood, P Slater, JFW Deakin, PH Hutson
Neuroreport 10 (3), 461-465, 1999
1171999
Anticonvulsant activity of glycine-site NMDA antagonists. 2. trans 2-carboxy-4-substituted tetrahydroquinolines.
RW Carling, PD Leeson, AM Moseley, JD Smith, K Saywell, ...
Bioorganic & Medicinal Chemistry Letters 3 (1), 65-70, 1993
1171993
Development of an intact cell reporter gene β-lactamase assay for G protein-coupled receptors for high-throughput screening
P Kunapuli, R Ransom, KL Murphy, D Pettibone, J Kerby, S Grimwood, ...
Analytical biochemistry 314 (1), 16-29, 2003
1142003
Recombinant Human NMDA Homomeric NR1 Receptors Expressed in Mammalian Cells Form a High‐Affinity Glycine Antagonist Binding Site
S Grimwood, B Le Bourdellès, PJ Whiting
Journal of neurochemistry 64 (2), 525-530, 1995
1051995
Characterization of the binding of [3H] L-689,560, an antagonist for the glycine site on the N-methyl-D-aspartate receptor, to rat brain membranes.
S Grimwood, AM Moseley, RW Carling, PD Leeson, AC Foster
Molecular pharmacology 41 (5), 923-930, 1992
961992
4-Substituted-3-phenylquinolin-2(1H)-ones:  Acidic and Nonacidic Glycine Site N-Methyl-d-aspartate Antagonists with in Vivo Activity
RW Carling, PD Leeson, KW Moore, CR Moyes, M Duncton, ML Hudson, ...
Journal of medicinal chemistry 40 (5), 754-765, 1997
921997
Discovery of the Potent and Selective M1 PAM-Agonist N-[(3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2 …
JE Davoren, CW Lee, M Garnsey, MA Brodney, J Cordes, K Dlugolenski, ...
Journal of medicinal chemistry 59 (13), 6313-6328, 2016
872016
Kynurenic acid analogues with improved affinity and selectivity for the glycine site on the N-methyl-D-aspartate receptor from rat brain.
AC Foster, JA Kemp, PD Leeson, S Grimwood, AE Donald, GR Marshall, ...
Molecular pharmacology 41 (5), 914-922, 1992
831992
Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo
RJ Kleiman, DS Chapin, C Christoffersen, J Freeman, KR Fonseca, ...
Journal of Pharmacology and Experimental Therapeutics 341 (2), 396-409, 2012
822012
Application of cross-species PET imaging to assess neurotransmitter release in brain
SJ Finnema, M Scheinin, M Shahid, J Lehto, E Borroni, B Bang-Andersen, ...
Psychopharmacology 232, 4129-4157, 2015
812015
Pharmacological characterization of 2-methyl-N-((2′-(pyrrolidin-1-ylsulfonyl) biphenyl-4-yl) methyl) propan-1-amine (PF-04455242), a high-affinity antagonist selective for κ …
S Grimwood, Y Lu, AW Schmidt, MA Vanase-Frawley, A Sawant-Basak, ...
Journal of Pharmacology and Experimental Therapeutics 339 (2), 555-566, 2011
692011
Generation and Characterisation of Stable Cell Lines Expressing Recombinant Human N‐Methyl‐d‐Aspartate Receptor Subtypes
S Grimwood, B Le Bourdellès, JR Atack, C Barton, W Cockett, SM Cook, ...
Journal of neurochemistry 66 (6), 2239-2247, 1996
681996
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