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X. Long Zheng, M.D., Ph.D.
X. Long Zheng, M.D., Ph.D.
Professor and Chair of Pathology and Laboratory Medicine
Dirección de correo verificada de kumc.edu
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Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura
X Zheng, D Chung, TK Takayama, EM Majerus, JE Sadler, K Fujikawa
Journal of Biological Chemistry 276 (44), 41059-41063, 2001
10562001
Effect of plasma exchange on plasma ADAMTS13 metalloprotease activity, inhibitor level, and clinical outcome in patients with idiopathic and nonidiopathic thrombotic …
XL Zheng, RM Kaufman, LT Goodnough, JE Sadler
Blood 103 (11), 4043-4049, 2004
5202004
Pathogenesis of thrombotic microangiopathies
XL Zheng, JE Sadler
Annu. Rev. Pathol. Mech. Dis. 3, 249-277, 2008
2762008
ISTH guidelines for treatment of thrombotic thrombocytopenic purpura
XL Zheng, SK Vesely, SR Cataland, P Coppo, B Geldziler, A Iorio, ...
Journal of Thrombosis and Haemostasis 18 (10), 2496-2502, 2020
2412020
Cleavage of von Willebrand factor requires the spacer domain of the metalloprotease ADAMTS13
X Zheng, K Nishio, EM Majerus, JE Sadler
Journal of Biological Chemistry 278 (32), 30136-30141, 2003
2332003
ADAMTS13 and von Willebrand factor in thrombotic thrombocytopenic purpura
XL Zheng
Annual review of medicine 66, 211-225, 2015
2322015
Binding of platelet glycoprotein Ibα to von Willebrand factor domain A1 stimulates the cleavage of the adjacent domain A2 by ADAMTS13
K Nishio, PJ Anderson, XL Zheng, JE Sadler
Proceedings of the National Academy of Sciences 101 (29), 10578-10583, 2004
1912004
Incomplete embryonic lethality and fatal neonatal hemorrhage caused by prothrombin deficiency in mice
J Xue, Q Wu, LA Westfield, EA Tuley, D Lu, Q Zhang, K Shim, X Zheng, ...
Proceedings of the National Academy of Sciences 95 (13), 7603-7607, 1998
1861998
ISTH guidelines for the diagnosis of thrombotic thrombocytopenic purpura
XL Zheng, SK Vesely, SR Cataland, P Coppo, B Geldziler, A Iorio, ...
Journal of Thrombosis and Haemostasis 18 (10), 2486-2495, 2020
1732020
Remission of chronic thrombotic thrombocytopenic purpura after treatment with cyclophosphamide and rituximab
X Zheng, AM Pallera, LT Goodnough, JE Sadler, MA Blinder
Annals of internal medicine 138 (2), 105-108, 2003
1622003
Structure–function and regulation of ADAMTS‐13 protease
XL Zheng
Journal of Thrombosis and Haemostasis 11, 11-23, 2013
1532013
Cleavage of the ADAMTS13 propeptide is not required for protease activity
EM Majerus, X Zheng, EA Tuley, JE Sadler
Journal of Biological Chemistry 278 (47), 46643-46648, 2003
1532003
Multiple domains of ADAMTS13 are targeted by autoantibodies against ADAMTS13 in patients with acquired idiopathic thrombotic thrombocytopenic purpura
XL Zheng, HM Wu, D Shang, E Falls, CG Skipwith, SR Cataland, ...
Haematologica 95 (9), 1555, 2010
1452010
Thrombotic thrombocytopenic purpura: pathogenesis, diagnosis and potential novel therapeutics
M Saha, JK McDaniel, XL Zheng
Journal of Thrombosis and Haemostasis 15 (10), 1889-1900, 2017
1442017
The cooperative activity between the carboxyl-terminal TSP1 repeats and the CUB domains of ADAMTS13 is crucial for recognition of von Willebrand factor under flow
P Zhang, W Pan, AH Rux, BS Sachais, XL Zheng
Blood, The Journal of the American Society of Hematology 110 (6), 1887-1894, 2007
1442007
Inflammatory cytokines inhibit ADAMTS13 synthesis in hepatic stellate cells and endothelial cells
WJ Cao, M Niiya, XW Zheng, DZ Shang, XL Zheng
Journal of Thrombosis and Haemostasis 6 (7), 1233-1235, 2008
1412008
Gain-of-function ADAMTS13 variants that are resistant to autoantibodies against ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura
C Jian, J Xiao, L Gong, CG Skipwith, SY Jin, HC Kwaan, XL Zheng
Blood, The Journal of the American Society of Hematology 119 (16), 3836-3843, 2012
1392012
Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site
TJ Raife, W Cao, BS Atkinson, B Bedell, RR Montgomery, SR Lentz, ...
Blood, The Journal of the American Society of Hematology 114 (8), 1666-1674, 2009
1352009
The proximal carboxyl-terminal domains of ADAMTS13 determine substrate specificity and are all required for cleavage of von Willebrand factor
J Ai, P Smith, S Wang, P Zhang, XL Zheng
Journal of Biological Chemistry 280 (33), 29428-29434, 2005
1342005
Crystal structure of enteropeptidase light chain complexed with an analog of the trypsinogen activation peptide
D Lu, K Fütterer, S Korolev, X Zheng, K Tan, G Waksman, JE Sadler
Journal of molecular biology 292 (2), 361-373, 1999
1311999
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