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Weikang Ma
Weikang Ma
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Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers
RL Anderson, DV Trivedi, SS Sarkar, M Henze, W Ma, H Gong, ...
Proceedings of the National Academy of Sciences 115 (35), E8143-E8152, 2018
2872018
Myosin head configurations in resting and contracting murine skeletal muscle
W Ma, H Gong, T Irving
International journal of molecular sciences 19 (9), 2643, 2018
532018
Thick-filament extensibility in intact skeletal muscle
W Ma, H Gong, B Kiss, EJ Lee, H Granzier, T Irving
Biophysical journal 115 (8), 1580-1588, 2018
502018
The super-relaxed state and length dependent activation in porcine myocardium
W Ma, M Henze, RL Anderson, H Gong, FL Wong, CL Del Rio, T Irving
Circulation research 129 (6), 617-630, 2021
452021
Nebulin stiffens the thin filament and augments cross-bridge interaction in skeletal muscle
B Kiss, EJ Lee, W Ma, FW Li, P Tonino, SM Mijailovich, TC Irving, ...
Proceedings of the National Academy of Sciences 115 (41), 10369-10374, 2018
392018
Cardiac myosin activation with 2-deoxy-ATP via increased electrostatic interactions with actin
JD Powers, CC Yuan, KJ McCabe, JD Murray, MC Childers, GV Flint, ...
Proceedings of the National Academy of Sciences 116 (23), 11502-11507, 2019
362019
The myosin interacting-heads motif present in live tarantula muscle explains tetanic and posttetanic phosphorylation mechanisms
R Padrón, W Ma, S Duno-Miranda, N Koubassova, KH Lee, A Pinto, ...
Proceedings of the National Academy of Sciences 117 (22), 11865-11874, 2020
332020
KBTBD13 is an actin-binding protein that modulates muscle kinetics
JM De Winter, JP Molenaar, M Yuen, R Van Der Pijl, S Shen, S Conijn, ...
The Journal of clinical investigation 130 (2), 754-767, 2020
332020
Structural and functional impact of troponin C-mediated Ca2+ sensitization on myofilament lattice spacing and cross-bridge mechanics in mouse cardiac muscle
D Gonzalez-Martinez, JR Johnston, M Landim-Vieira, W Ma, O Antipova, ...
Journal of molecular and cellular cardiology 123, 26-37, 2018
302018
Mechanistic insights into enhancement or inhibition of phase separation by different polyubiquitin chains
TP Dao, Y Yang, MF Presti, MS Cosgrove, JB Hopkins, W Ma, SN Loh, ...
EMBO reports 23 (8), e55056, 2022
292022
Small angle X-ray diffraction as a tool for structural characterization of muscle disease
W Ma, TC Irving
International Journal of Molecular Sciences 23 (6), 3052, 2022
292022
Dysfunctional sarcomere contractility contributes to muscle weakness in ACTA1‐related nemaline myopathy (NEM3)
B Joureau, JM de Winter, S Conijn, SJP Bogaards, I Kovacevic, ...
Annals of neurology 83 (2), 269-282, 2018
292018
MuscleX: software suite for diffraction X-ray imaging V1. 13.1
J Jiratrakanvong, J Shao, M Menendez, X Li, J Li, W Ma, G Agam, T Irving
Zenodo: Geneva, Switzerland, 2018
272018
Molecular basis of force-pCa relation in MYL2 cardiomyopathy mice: Role of the super-relaxed state of myosin
CC Yuan, K Kazmierczak, J Liang, W Ma, TC Irving, D Szczesna-Cordary
Proceedings of the National Academy of Sciences 119 (8), e2110328119, 2022
252022
Cardiac myosin filaments are directly regulated by calcium
W Ma, H Gong, L Qi, S Nag, TC Irving
242022
Fast skeletal myosin-binding protein-C regulates fast skeletal muscle contraction
T Song, JW McNamara, W Ma, M Landim-Vieira, KH Lee, LA Martin, ...
Proceedings of the National Academy of Sciences 118 (17), e2003596118, 2021
222021
Myosin dynamics during relaxation in mouse soleus muscle and modulation by 2′‐deoxy‐ATP
W Ma, M Childers, J Murray, F Moussavi‐Harami, H Gong, R Weiss, ...
The Journal of physiology 598 (22), 5165-5182, 2020
222020
Titin force in muscle cells alters lattice order, thick and thin filament protein formation
AL Hessel, W Ma, N Mazara, PE Rice, D Nissen, H Gong, M Kuehn, ...
Proceedings of the National Academy of Sciences 119 (48), e2209441119, 2022
202022
Two classes of myosin inhibitors, para-nitroblebbistatin and mavacamten, stabilize β-cardiac myosin in different structural and functional states
SK Gollapudi, W Ma, S Chakravarthy, AC Combs, N Sa, S Langer, ...
Journal of molecular biology 433 (23), 167295, 2021
202021
Structural OFF/ON transitions of myosin in relaxed porcine myocardium predict calcium-activated force
W Ma, TS McMillen, MC Childers, H Gong, M Regnier, T Irving
Proceedings of the National Academy of Sciences 120 (5), e2207615120, 2023
182023
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