| Discovery of a first-in-class receptor interacting protein 1 (RIP1) kinase specific clinical candidate (GSK2982772) for the treatment of inflammatory diseases PA Harris, SB Berger, JU Jeong, R Nagilla, D Bandyopadhyay, ... Journal of medicinal chemistry 60 (4), 1247-1261, 2017 | 416 | 2017 |
| Thiamin biosynthesis in prokaryotes TP Begley, DM Downs, SE Ealick, FW McLafferty, APGM Van Loon, ... Archives of microbiology 171, 293-300, 1999 | 361 | 1999 |
| DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors PA Harris, BW King, D Bandyopadhyay, SB Berger, N Campobasso, ... Journal of medicinal chemistry 59 (5), 2163-2178, 2016 | 246 | 2016 |
| Discovery of small molecule RIP1 kinase inhibitors for the treatment of pathologies associated with necroptosis PA Harris, D Bandyopadhyay, SB Berger, N Campobasso, CA Capriotti, ... ACS medicinal chemistry letters 4 (12), 1238-1243, 2013 | 148 | 2013 |
| Discovery and characterization of a cell-permeable, small-molecule c-Abl kinase activator that binds to the myristoyl binding site J Yang, N Campobasso, MP Biju, K Fisher, XQ Pan, J Cottom, S Galbraith, ... Chemistry & biology 18 (2), 177-186, 2011 | 137 | 2011 |
| Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia MB Pappalardi, K Keenan, M Cockerill, WA Kellner, A Stowell, C Sherk, ... Nature cancer 2 (10), 1002-1017, 2021 | 118 | 2021 |
| Discovery of tertiary sulfonamides as potent liver X receptor antagonists WJ Zuercher, RG Buckholz, N Campobasso, JL Collins, CM Galardi, ... Journal of medicinal chemistry 53 (8), 3412-3416, 2010 | 102 | 2010 |
| Crystal Structure of 4-Methyl-5-β-hydroxyethylthiazole Kinase from Bacillus subtilis at 1.5 Å Resolution, N Campobasso, II Mathews, TP Begley, SE Ealick Biochemistry 39 (27), 7868-7877, 2000 | 84 | 2000 |
| 3-hydroxy-3-methylglutaryl–CoA synthase intermediate complex observed in “real-time” MJ Theisen, I Misra, D Saadat, N Campobasso, HM Miziorko, ... Proceedings of the National Academy of Sciences 101 (47), 16442-16447, 2004 | 80 | 2004 |
| Discovery of a novel 2, 6-disubstituted glucosamine series of potent and selective hexokinase 2 inhibitors H Lin, J Zeng, R Xie, MJ Schulz, R Tedesco, J Qu, KF Erhard, JF Mack, ... ACS medicinal chemistry letters 7 (3), 217-222, 2016 | 79 | 2016 |
| Staphylococcus aureus 3-hydroxy-3-methylglutaryl-CoA synthase: crystal structure and mechanism N Campobasso, M Patel, IE Wilding, H Kallender, M Rosenberg, ... Journal of Biological Chemistry 279 (43), 44883-44888, 2004 | 73 | 2004 |
| Structure-based design of potent and selective 3-phosphoinositide-dependent kinase-1 (PDK1) inhibitors JR Medina, CJ Becker, CW Blackledge, C Duquenne, Y Feng, SW Grant, ... Journal of medicinal chemistry 54 (6), 1871-1895, 2011 | 70 | 2011 |
| Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure MC Jaye, JA Krawiec, N Campobasso, A Smallwood, C Qiu, Q Lu, ... Journal of medicinal chemistry 48 (17), 5419-5422, 2005 | 68 | 2005 |
| Structure-Guided Design of N-Phenyl Tertiary Amines as Transrepression-Selective Liver X Receptor Modulators with Anti-Inflammatory Activity EY Chao, JA Caravella, MA Watson, N Campobasso, S Ghisletti, AN Billin, ... Journal of medicinal chemistry 51 (18), 5758-5765, 2008 | 64 | 2008 |
| Long-range inhibitor-induced conformational regulation of human IRE1α endoribonuclease activity NO Concha, A Smallwood, W Bonnette, R Totoritis, G Zhang, ... Molecular pharmacology 88 (6), 1011-1023, 2015 | 57 | 2015 |
| Structural Characterization of the Enzyme−Substrate, Enzyme−Intermediate, and Enzyme−Product Complexes of Thiamin Phosphate Synthase, DH Peapus, HJ Chiu, N Campobasso, JJ Reddick, TP Begley, SE Ealick Biochemistry 40 (34), 10103-10114, 2001 | 52 | 2001 |
| Crystal Structure of Thiaminase-I from Bacillus thiaminolyticus at 2.0 Å Resolution, N Campobasso, CA Costello, C Kinsland, TP Begley, SE Ealick Biochemistry 37 (45), 15981-15989, 1998 | 51 | 1998 |
| Cofactor biosynthesis: a mechanistic perspective TP Begley, C Kinsland, S Taylor, M Tandon, R Nicewonger, M Wu, ... Biosynthesis: Polyketides and Vitamins, 93-142, 1998 | 44 | 1998 |
| Refinement of a Model for the Nitrogenase Mo Fe Cluster Using Single‐Crystal Mo and Fe EXAFS SP Cramer, J Chen, J Christiansen, N Campobasso, JT Bolin, ... Angewandte Chemie International Edition in English 32 (11), 1592-1594, 1993 | 43 | 1993 |
| Discovery and lead-optimization of 4, 5-dihydropyrazoles as mono-kinase selective, orally bioavailable and efficacious inhibitors of receptor interacting protein 1 (RIP1) kinase PA Harris, N Faucher, N George, PM Eidam, BW King, GV White, ... Journal of Medicinal Chemistry 62 (10), 5096-5110, 2019 | 42 | 2019 |
