| Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations P Buczkowicz, C Hoeman, P Rakopoulos, S Pajovic, L Letourneau, ... Nature genetics 46 (5), 451-456, 2014 | 625 | 2014 |
| Hedgehog signaling in the maintenance of cancer stem cells CR Cochrane, A Szczepny, DN Watkins, JE Cain Cancers 7 (3), 1554-1585, 2015 | 255 | 2015 |
| Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing CH Lim, Q Sun, K Ratti, SH Lee, Y Zheng, M Takeo, W Lee, P Rabbani, ... Nature communications 9 (1), 4903, 2018 | 222 | 2018 |
| Integrated proteogenomic characterization across major histological types of pediatric brain cancer F Petralia, N Tignor, B Reva, M Koptyra, S Chowdhury, D Rykunov, A Krek, ... Cell 183 (7), 1962-1985. e31, 2020 | 209 | 2020 |
| Canonical WNT/β-catenin signaling is required for ureteric branching D Bridgewater, B Cox, J Cain, A Lau, V Athaide, PS Gill, S Kuure, K Sainio, ... Developmental biology 317 (1), 83-94, 2008 | 167 | 2008 |
| Genetics of renal hypoplasia: insights into the mechanisms controlling nephron endowment JE Cain, V Di Giovanni, J Smeeton, ND Rosenblum Pediatric research 68 (2), 91-98, 2010 | 111 | 2010 |
| GLI3 repressor controls functional development of the mouse ureter JE Cain, E Islam, F Haxho, J Blake, ND Rosenblum The Journal of clinical investigation 121 (3), 1199-1206, 2011 | 85 | 2011 |
| GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells JE Cain, E Islam, F Haxho, L Chen, D Bridgewater, E Nieuwenhuis, ... PloS one 4 (10), e7313, 2009 | 79 | 2009 |
| ADAM 17 selectively activates the IL‐6 trans‐signaling/ERK MAPK axis in KRAS‐addicted lung cancer MI Saad, S Alhayyani, L McLeod, L Yu, M Alanazi, V Deswaerte, K Tang, ... EMBO molecular medicine 11 (4), e9976, 2019 | 77 | 2019 |
| The role of canonical and non-canonical Hedgehog signaling in tumor progression in a mouse model of small cell lung cancer A Szczepny, S Rogers, WSN Jayasekara, K Park, RA McCloy, ... Oncogene 36 (39), 5544-5550, 2017 | 63 | 2017 |
| BMP receptor ALK3 controls collecting system development S Hartwig, D Bridgewater, V Di Giovanni, J Cain, Y Mishina, ... Journal of the American Society of Nephrology 19 (1), 117-124, 2008 | 63 | 2008 |
| Control of mammalian kidney development by the Hedgehog signaling pathway JE Cain, ND Rosenblum Pediatric nephrology 26, 1365-1371, 2011 | 55 | 2011 |
| Pharmaco-proteogenomic profiling of pediatric diffuse midline glioma to inform future treatment strategies IJ Findlay, GN De Iuliis, RJ Duchatel, ER Jackson, NA Vitanza, JE Cain, ... Oncogene 41 (4), 461-475, 2022 | 54 | 2022 |
| Exogenous BMP-4 amplifies asymmetric ureteric branching in the developing mouse kidney in vitro JE Cain, T Nion, D Jeulin, JF Bertram Kidney international 67 (2), 420-431, 2005 | 50 | 2005 |
| Bone morphogenetic protein signaling in the developing kidney: present and future JE Cain, S Hartwig, JF Bertram, ND Rosenblum Differentiation 76 (8), 831-842, 2008 | 49 | 2008 |
| Imipridones affect tumor bioenergetics and promote cell lineage differentiation in diffuse midline gliomas JM Przystal, C Cianciolo Cosentino, S Yadavilli, J Zhang, S Laternser, ... Neuro-oncology 24 (9), 1438-1451, 2022 | 48 | 2022 |
| β-catenin causes renal dysplasia via upregulation of Tgfβ2 and Dkk1 D Bridgewater, V Di Giovanni, JE Cain, B Cox, M Jakobson, K Sainio, ... Journal of the American Society of Nephrology 22 (4), 718-731, 2011 | 47 | 2011 |
| Cre-dependent DNA recombination activates a STING-dependent innate immune response G Pépin, J Ferrand, K Höning, WSN Jayasekara, JE Cain, MA Behlke, ... Nucleic acids research 44 (11), 5356-5364, 2016 | 46 | 2016 |
| Prevailing importance of the hedgehog signaling pathway and the potential for treatment advancement in sarcoma FC Kelleher, JE Cain, JM Healy, DN Watkins, DM Thomas Pharmacology & therapeutics 136 (2), 153-168, 2012 | 46 | 2012 |
| Low-dose histone deacetylase inhibitor treatment leads to tumor growth arrest and multi-lineage differentiation of malignant rhabdoid tumors A Muscat, D Popovski, WSN Jayasekara, FJ Rossello, M Ferguson, ... Clinical Cancer Research 22 (14), 3560-3570, 2016 | 45 | 2016 |
