| Structural basis for a bimodal allosteric mechanism of general anesthetic modulation in pentameric ligand-gated ion channels Z Fourati, RJ Howard, SA Heusser, H Hu, RR Ruza, L Sauguet, E Lindahl, ... Cell reports 23 (4), 993-1004, 2018 | 34 | 2018 |
| Acid-sensing ion channels as potential therapeutic targets SA Heusser, SA Pless Trends in pharmacological sciences 42 (12), 1035-1050, 2021 | 32 | 2021 |
| Mechanism and site of action of big dynorphin on ASIC1a CB Borg, N Braun, SA Heusser, Y Bay, D Weis, I Galleano, C Lund, ... Proceedings of the National Academy of Sciences 117 (13), 7447-7454, 2020 | 32 | 2020 |
| Allosteric potentiation of a ligand-gated ion channel is mediated by access to a deep membrane-facing cavity SA Heusser, M Lycksell, X Wang, SE McComas, RJ Howard, E Lindahl Proceedings of the National Academy of Sciences 115 (42), 10672-10677, 2018 | 24 | 2018 |
| Functional validation of virtual screening for novel agents with general anesthetic action at ligand-gated ion channels SA Heusser, RJ Howard, CM Borghese, MA Cullins, T Broemstrup, ... Molecular pharmacology 84 (5), 670-678, 2013 | 23 | 2013 |
| Markov state models of proton- and pore-dependent activation in a pentameric ligand-gated ion channel C Bergh, SA Heusser, R Howard, E Lindahl eLife, 2021 | 13 | 2021 |
| Structure-guided unlocking of NaX reveals a non-selective tetrodotoxin-sensitive cation channel CL Noland, HC Chua, M Kschonsak, SA Heusser, N Braun, T Chang, ... Nature Communications 13 (1), 1416, 2022 | 12 | 2022 |
| Functional characterization of neurotransmitter activation and modulation in a nematode model ligand‐gated ion channel SA Heusser, Ö Yoluk, G Klement, EA Riederer, E Lindahl, RJ Howard Journal of neurochemistry 138 (2), 243-253, 2016 | 6 | 2016 |
| Conformational decoupling in acid-sensing ion channels uncovers mechanism and stoichiometry of PcTx1-mediated inhibition SA Heusser, CB Borg, JM Colding, SA Pless Elife 11, e73384, 2022 | 5 | 2022 |
| Dynamic conformational changes of acid-sensing ion channels in different desensitizing conditions CM Holm, AB Topaktas, J Dannesboe, SA Pless, SA Heusser Biophysical journal, 2024 | 1 | 2024 |
| Protein semisynthesis underscores the role of a conserved lysine in activation and desensitization of acid-sensing ion channels D Sarkar, I Galleano, SA Heusser, SY Ou, GR Uzun, KK Khoo, ... Cell Chemical Biology, 2023 | 1 | 2023 |
| Allosteric modulation of pentameric ligand-gated ion channels by general anesthetics SA Heusser Department of Biochemistry and Biophysics, Stockholm University, 2018 | | 2018 |
