van de Steeg, E
van de Steeg, E
scientist, TNO Zeist
Verified email at
Cited by
Cited by
Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Aβ42 accumulation in a novel Alzheimer transgenic model
C Casas, N Sergeant, JM Itier, V Blanchard, O Wirths, N Van Der Kolk, ...
The American journal of pathology 165 (4), 1289-1300, 2004
Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver
E van de Steeg, V Stránecký, H Hartmannová, L Nosková, M Hřebíček, ...
The Journal of clinical investigation 122 (2), 519-528, 2012
Organic anion transporting polypeptide 1a/1b–knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs
E van de Steeg, E Wagenaar, CMM van der Kruijssen, JEC Burggraaff, ...
The Journal of clinical investigation 120 (8), 2010
Human ontogeny of drug transporters: review and recommendations of the pediatric transporter working group
KLR Brouwer, LM Aleksunes, B Brandys, GP Giacoia, G Knipp, ...
Clinical Pharmacology & Therapeutics 98 (3), 266-287, 2015
Methotrexate pharmacokinetics in transgenic mice with liver-specific expression of human organic anion-transporting polypeptide 1B1 (SLCO1B1)
E van de Steeg, CMM van der Kruijssen, E Wagenaar, JEC Burggraaff, ...
Drug Metabolism and Disposition 37 (2), 277-281, 2009
Influence of Human OATP1B1, OATP1B3, and OATP1A2 on the Pharmacokinetics of Methotrexate and Paclitaxel in Humanized Transgenic MiceRole of Human OATP1A/1Bs in Paclitaxel and …
E van de Steeg, A van Esch, E Wagenaar, KE Kenworthy, AH Schinkel
Clinical cancer research 19 (4), 821-832, 2013
A new approach to predict human intestinal absorption using porcine intestinal tissue and biorelevant matrices
J Westerhout, E van de Steeg, D Grossouw, EE Zeijdner, CAM Krul, ...
European Journal of Pharmaceutical Sciences 63, 167-177, 2014
Variability in mass spectrometry-based quantification of clinically relevant drug transporters and drug metabolizing enzymes
C Wegler, FZ Gaugaz, TB Andersson, JR Wiśniewski, D Busch, C Gröer, ...
Molecular pharmaceutics 14 (9), 3142-3151, 2017
Functions of OATP1A and 1B transporters in vivo: insights from mouse models
D Iusuf, E van de Steeg, AH Schinkel
Trends in pharmacological sciences 33 (2), 100-108, 2012
Quantifying phenotypic flexibility as the response to a high‐fat challenge test in different states of metabolic health
AFM Kardinaal, MJ van Erk, AE Dutman, JHM Stroeve, E van de Steeg, ...
The FASEB Journal 29 (11), 4600-4613, 2015
Regional expression levels of drug transporters and metabolizing enzymes along the pig and human intestinal tract and comparison with Caco-2 cells
SFC Vaessen, MMH van Lipzig, RHH Pieters, CAM Krul, HM Wortelboer, ...
Drug metabolism and disposition 45 (4), 353-360, 2017
Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein …
S Bosgra, E van de Steeg, ML Vlaming, KC Verhoeckx, MT Huisman, ...
European Journal of Pharmaceutical Sciences 65, 156-166, 2014
High Impact of Oatp1a/1b Transporters on In Vivo Disposition of the Hydrophobic Anticancer Drug PaclitaxelOatp1a/1b Affect Paclitaxel and Methotrexate Disposition
E Van de Steeg, A van Esch, E Wagenaar, CMM van der Kruijssen, ...
Clinical Cancer Research 17 (2), 294-301, 2011
Drug-drug interactions between rosuvastatin and oral antidiabetic drugs occurring at the level of OATP1B1
E van de Steeg, R Greupink, M Schreurs, IHG Nooijen, KCM Verhoeckx, ...
Drug Metabolism and Disposition 41 (3), 592-601, 2013
Species-dependent transport and modulation properties of human and mouse multidrug resistance protein 2 (MRP2/Mrp2, ABCC2/Abcc2)
C Zimmermann, K van de Wetering, E van de Steeg, E Wagenaar, C Vens, ...
Drug metabolism and disposition 36 (4), 631-640, 2008
Human OATP1B1, OATP1B3 and OATP1A2 can mediate the in vivo uptake and clearance of docetaxel
D Iusuf, JJMA Hendrikx, A van Esch, E van de Steeg, E Wagenaar, ...
International journal of cancer 136 (1), 225-233, 2015
Impact of abcc2 [multidrug resistance-associated protein (MRP) 2], abcc3 (MRP3), and abcg2 (breast cancer resistance protein) on the oral pharmacokinetics of methotrexate and …
MLH Vlaming, A van Esch, E van de Steeg, Z Pala, E Wagenaar, ...
Drug metabolism and disposition 39 (8), 1338-1344, 2011
Organic anion-transporting polypeptide 1B1 mediates transport of Gimatecan and BNP1350 and can be inhibited by several classic ATP-binding cassette (ABC) B1 and/or ABCG2 inhibitors
RL Oostendorp, E van de Steeg, CMM van der Kruijssen, JH Beijnen, ...
Drug metabolism and disposition 37 (4), 917-923, 2009
Hepatocyte hopping of OATP1B substrates contributes to efficient hepatic detoxification
D Iusuf, E Van De Steeg, AH Schinkel
Clinical Pharmacology & Therapeutics 92 (5), 559-562, 2012
Mechanisms and immunomodulatory properties of pre-and probiotics
VBM Peters, E Van De Steeg, J Van Bilsen, M Meijerink
Beneficial microbes 10 (3), 225-236, 2019
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