| Role of changes in SARS-CoV-2 spike protein in the interaction with the human ACE2 receptor: An in silico analysis JT Ortega, ML Serrano, FH Pujol, HR Rangel EXCLI journal 19, 410, 2020 | 359 | 2020 |
| Unrevealing sequence and structural features of novel coronavirus using in silico approaches: The main protease as molecular target JT Ortega, ML Serrano, FH Pujol, HR Rangel EXCLI journal 19, 400, 2020 | 114 | 2020 |
| The role of the glycosyl moiety of myricetin derivatives in anti-HIV-1 activity in vitro JT Ortega, AI Suárez, ML Serrano, J Baptista, FH Pujol, HR Rangel AIDS research and therapy 14, 1-6, 2017 | 77 | 2017 |
| Class AG protein-coupled receptor antagonist famotidine as a therapeutic alternative against SARS-CoV2: an in silico analysis JT Ortega, ML Serrano, B Jastrzebska Biomolecules 10 (6), 954, 2020 | 62 | 2020 |
| Antiviral activity of flavonoids present in aerial parts of Marcetia taxifolia against Hepatitis B virus, Poliovirus, and Herpes Simplex Virus in vitro JT Ortega, ML Serrano, AI Suárez, J Baptista, FH Pujol, LV Cavallaro, ... EXCLI journal 18, 1037, 2019 | 40 | 2019 |
| Omicron SARS-CoV-2 variant spike protein shows an increased affinity to the human ACE2 receptor: an in silico analysis JT Ortega, B Jastrzebska, HR Rangel Pathogens 11 (1), 45, 2021 | 38 | 2021 |
| Mutations in the SARS-CoV-2 spike protein modulate the virus affinity to the human ACE2 receptor, an in silico analysis JT Ortega, FH Pujol, B Jastrzebska, HR Rangel EXCLI journal 20, 585, 2021 | 29 | 2021 |
| Flavonoids enhance rod opsin stability, folding, and self-association by directly binding to ligand-free opsin and modulating its conformation JT Ortega, T Parmar, B Jastrzebska Journal of Biological Chemistry 294 (20), 8101-8122, 2019 | 28 | 2019 |
| Protective effects of flavonoids in acute models of light-induced retinal degeneration JT Ortega, T Parmar, M Golczak, B Jastrzebska Molecular Pharmacology 99 (1), 60-77, 2021 | 26 | 2021 |
| Remarkable in vitro anti-HIV activity of new silver(I)– and gold(I)–N-heterocyclic carbene complexes. Synthesis, DNA binding and biological evaluation O Sánchez, S González, ÁR Higuera-Padilla, Y León, D Coll, ... Polyhedron 110, 14-23, 2016 | 23 | 2016 |
| Neuroinflammation as a therapeutic target in retinitis pigmentosa and quercetin as its potential modulator JT Ortega, B Jastrzebska Pharmaceutics 13 (11), 1935, 2021 | 22 | 2021 |
| Understanding Severe Acute Respiratory Syndrome Coronavirus 2 Replication to Design Efficient Drug Combination Therapies JT Ortega, JL Zambrano, B Jastrzebska, F Liprandi, HR Rangel, FH Pujol Intervirology, 1-8, 2020 | 20 | 2020 |
| Glycosylated Flavonoids from Psidium guineense as Major Inhibitors of HIV-1 Replication in vitro JT Ortega, O Estrada, ML Serrano, W Contreras, G Orsini, FH Pujol, ... Natural Product Communications 12 (7), 1934578X1701200712, 2017 | 17 | 2017 |
| The retinoid and non-retinoid ligands of the rod visual G protein-coupled receptor JT Ortega, B Jastrzebska International Journal of Molecular Sciences 20 (24), 6218, 2019 | 16 | 2019 |
| SARS-CoV-2 host tropism: An in silico analysis of the main cellular factors HR Rangel, JT Ortega, S Maksoud, FH Pujol, ML Serrano Virus Research 289, 198154, 2020 | 14 | 2020 |
| Specificity of the chromophore-binding site in human cone opsins K Katayama, S Gulati, JT Ortega, NS Alexander, W Sun, MM Shenouda, ... Journal of Biological Chemistry 294 (15), 6082-6093, 2019 | 12 | 2019 |
| Flavonoids improve the stability and function of P23H rhodopsin slowing down the progression of retinitis pigmentosa in mice JT Ortega, T Parmar, M Carmena‐Bargueño, H Pérez‐Sánchez, ... Journal of neuroscience research 100 (4), 1063-1083, 2022 | 11 | 2022 |
| Role of changes in SARS-CoV-2 spike protein in the interaction with the human ACE2 receptor: An in silico analysis. EXCLI J. 2020; 19: 410-7 JT Ortega, ML Serrano, FH Pujol, HR Rangel | 11 | |
| Systematic profiling of temperature-and retinal-sensitive rhodopsin variants by deep mutational scanning AG McKee, CP Kuntz, JT Ortega, H Woods, V Most, FJ Roushar, J Meiler, ... Journal of Biological Chemistry 297 (6), 2021 | 10 | 2021 |
| Retinoid analogs and polyphenols as potential therapeutics for age-related macular degeneration T Parmar, JT Ortega, B Jastrzebska Experimental Biology and Medicine 245 (17), 1615-1625, 2020 | 10 | 2020 |
Hector R RangelInstituto Venezolano de Investigaciones CientificasVerified email at ivic.gob.ve
