| Ultrahigh resolution drug design I: Details of interactions in human aldose reductase–inhibitor complex at 0.66 Å EI Howard, R Sanishvili, RE Cachau, A Mitschler, B Chevrier, P Barth, ... Proteins: Structure, Function, and Bioinformatics 55 (4), 792-804, 2004 | 355 | 2004 |
| Interaction of water with α, α-trehalose in solution: molecular dynamics simulation approach MC Donnamaria, EI Howard, JR Grigera Journal of the Chemical Society, Faraday Transactions 90 (18), 2731-2735, 1994 | 165 | 1994 |
| Electrostatic complementarity in an aldose reductase complex from ultra-high-resolution crystallography and first-principles calculations N Muzet, B Guillot, C Jelsch, E Howard, C Lecomte Proceedings of the National Academy of Sciences 100 (15), 8742-8747, 2003 | 131 | 2003 |
| Binding of aldose reductase inhibitors: correlation of crystallographic and mass spectrometric studies H Rogniaux, A Van Dorsselaer, P Barth, JF Biellmann, J Barbanton, ... Journal of the American Society for Mass Spectrometry 10 (7), 635-647, 1999 | 121 | 1999 |
| The effect of stereochemistry upon carbohydrate hydration. A molecular dynamics simulation of β-d-galactopyranose and (α, β)-d-talopyranose SA Galema, E Howard, JBFN Engberts, JR Grigera Carbohydrate research 265 (2), 215-225, 1994 | 96 | 1994 |
| Neutron macromolecular crystallography with LADI-III MP Blakeley, SCM Teixeira, I Petit-Haertlein, I Hazemann, A Mitschler, ... Acta Crystallographica Section D: Biological Crystallography 66 (11), 1198-1205, 2010 | 93 | 2010 |
| Neutron structure of type‐III antifreeze protein allows the reconstruction of AFP–ice interface EI Howard, MP Blakeley, M Haertlein, IP Haertlein, A Mitschler, SJ Fisher, ... Journal of Molecular Recognition 24 (4), 724-732, 2011 | 89 | 2011 |
| Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of … MC Van Zandt, DL Whitehouse, A Golebiowski, MK Ji, M Zhang, ... Journal of medicinal chemistry 56 (6), 2568-2580, 2013 | 85 | 2013 |
| Design and synthesis of highly potent and selective (2-arylcarbamoyl-phenoxy)-acetic acid inhibitors of aldose reductase for treatment of chronic diabetic complications MC Van Zandt, EO Sibley, EE McCann, KJ Combs, B Flam, DR Sawicki, ... Bioorganic & medicinal chemistry 12 (21), 5661-5675, 2004 | 74 | 2004 |
| Production of crystals of human aldose reductase with very high resolution diffraction V Lamour, P Barth, H Rogniaux, A Poterszman, E Howard, A Mitschler, ... Acta Crystallographica Section D: Biological Crystallography 55 (3), 721-723, 1999 | 50 | 1999 |
| Structural Basis of Outstanding Multivalent Effects in Jack Bean α‐Mannosidase Inhibition E Howard, A Cousido‐Siah, ML Lepage, JP Schneider, A Bodlenner, ... Angewandte Chemie International Edition 57 (27), 8002-8006, 2018 | 45 | 2018 |
| The structure of human aldose reductase bound to the inhibitor IDD384 V Calderone, B Chevrier, M Van Zandt, V Lamour, E Howard, ... Acta Crystallographica Section D: Biological Crystallography 56 (5), 536-540, 2000 | 40 | 2000 |
| High-resolution neutron and X-ray diffraction room-temperature studies of an H-FABP–oleic acid complex: study of the internal water cluster and ligand binding by a transferred … EI Howard, B Guillot, MP Blakeley, M Haertlein, M Moulin, A Mitschler, ... IUCrJ 3 (2), 115-126, 2016 | 38 | 2016 |
| Model of the catalytic mechanism of human aldose reductase based on quantum chemical calculations R Cachau, E Howard, P Barth, A Mitschler, B Chevrier, V Lamour, ... Le Journal de Physique IV 10 (PR10), Pr10-3-Pr10-13, 2000 | 35 | 2000 |
| New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM F Fadel, Y Zhao, R Cachau, A Cousido-Siah, FX Ruiz, K Harlos, ... Acta Crystallographica Section D: Biological Crystallography 71 (7), 1455-1470, 2015 | 30 | 2015 |
| Post-translational modifications in DNA topoisomerase 2α highlight the role of a eukaryote-specific residue in the ATPase domain C Bedez, C Lotz, C Batisse, AV Broeck, RH Stote, E Howard, ... Scientific Reports 8 (1), 9272, 2018 | 27 | 2018 |
| Perdeuteration, purification, crystallization and preliminary neutron diffraction of an ocean pout type III antifreeze protein I Petit-Haertlein, MP Blakeley, E Howard, I Hazemann, A Mitschler, ... Acta Crystallographica Section F: Structural Biology and Crystallization …, 2009 | 27 | 2009 |
| A multicopy modeling of the water distribution in macromolecular crystals AD Podjarny, EI Howard, A Urzhumtsev, JR Grigera Proteins: Structure, Function, and Bioinformatics 28 (3), 303-312, 1997 | 24 | 1997 |
| Discovery of N-Substituted 3-Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase I and II MC Van Zandt, GE Jagdmann, DL Whitehouse, M Ji, J Savoy, O Potapova, ... Journal of medicinal chemistry 62 (17), 8164-8177, 2019 | 22 | 2019 |
| Perdeuteration: Improved visualization of solvent structure in neutron macromolecular crystallography SJ Fisher, MP Blakeley, EI Howard, I Petit-Haertlein, M Haertlein, ... Acta Crystallographica Section D: Biological Crystallography 70 (12), 3266-3272, 2014 | 22 | 2014 |
