Megan L. McCain
Megan L. McCain
Associate Professor of Biomedical Engineering and Stem Cell Biology & Regenerative Medicine
Verified email at - Homepage
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Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies
G Wang, ML McCain, L Yang, A He, FS Pasqualini, A Agarwal, H Yuan, ...
Nature medicine 20 (6), 616-623, 2014
A tissue-engineered jellyfish with biomimetic propulsion
JC Nawroth, H Lee, AW Feinberg, CM Ripplinger, ML McCain, ...
Nature biotechnology 30 (8), 792-797, 2012
Ensembles of engineered cardiac tissues for physiological and pharmacological study: heart on a chip
A Grosberg, PW Alford, ML McCain, KK Parker
Lab on a Chip 11 (24), 4165-4173, 2011
Microfluidic heart on a chip for higher throughput pharmacological studies
A Agarwal, JA Goss, A Cho, ML McCain, KK Parker
Lab on a Chip 13 (18), 3599-3608, 2013
Mechanotransduction: the role of mechanical stress, myocyte shape, and cytoskeletal architecture on cardiac function
ML McCain, KK Parker
Pflügers Archiv-European Journal of Physiology 462, 89-104, 2011
Micromolded gelatin hydrogels for extended culture of engineered cardiac tissues
ML McCain, A Agarwal, HW Nesmith, AP Nesmith, KK Parker
Biomaterials 35 (21), 5462-5471, 2014
Cooperative coupling of cell-matrix and cell–cell adhesions in cardiac muscle
ML McCain, H Lee, Y Aratyn-Schaus, AG Kléber, KK Parker
Proceedings of the National Academy of Sciences 109 (25), 9881-9886, 2012
Muscle on a chip: in vitro contractility assays for smooth and striated muscle
A Grosberg, AP Nesmith, JA Goss, MD Brigham, ML McCain, KK Parker
Journal of pharmacological and toxicological methods 65 (3), 126-135, 2012
Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip
ML McCain, SP Sheehy, A Grosberg, JA Goss, KK Parker
Proceedings of the National Academy of Sciences 110 (24), 9770-9775, 2013
Prolonged culture of aligned skeletal myotubes on micromolded gelatin hydrogels
A Bettadapur, GC Suh, NA Geisse, ER Wang, C Hua, HA Huber, ...
Scientific reports 6 (1), 28855, 2016
Micropatterning alginate substrates for in vitro cardiovascular muscle on a chip
A Agarwal, Y Farouz, AP Nesmith, LF Deravi, ML McCain, KK Parker
Advanced functional materials 23 (30), 3738-3746, 2013
Matrix elasticity regulates the optimal cardiac myocyte shape for contractility
ML McCain, H Yuan, FS Pasqualini, PH Campbell, KK Parker
American Journal of Physiology-Heart and Circulatory Physiology 306 (11 …, 2014
Connexin 43 expression delineates two discrete pathways in the human atrioventricular junction
WJ Hucker, ML Mccain, JI Laughner, PA Iaizzo, IR Efimov
The Anatomical Record: Advances in Integrative Anatomy and Evolutionary …, 2008
Human airway musculature on a chip: an in vitro model of allergic asthmatic bronchoconstriction and bronchodilation
AP Nesmith, A Agarwal, ML McCain, KK Parker
Lab on a chip 14 (20), 3925-3936, 2014
Connexin43 ablation in foetal atrial myocytes decreases electrical coupling, partner connexins, and sodium current
T Desplantez, ML McCain, P Beauchamp, G Rigoli, B Rothen-Rutishauser, ...
Cardiovascular research 94 (1), 58-65, 2012
Cell-to-cell coupling in engineered pairs of rat ventricular cardiomyocytes: relation between Cx43 immunofluorescence and intercellular electrical conductance
ML McCain, T Desplantez, NA Geisse, B Rothen-Rutishauser, H Oberer, ...
American journal of physiology-heart and circulatory physiology 302 (2 …, 2012
Featured Article: TGF-β1 dominates extracellular matrix rigidity for inducing differentiation of human cardiac fibroblasts to myofibroblasts
N Cho, SE Razipour, ML McCain
Experimental Biology and Medicine 243 (7), 601-612, 2018
Electrical coupling and propagation in engineered ventricular myocardium with heterogeneous expression of connexin43
P Beauchamp, T Desplantez, ML McCain, W Li, A Asimaki, G Rigoli, ...
Circulation research 110 (11), 1445-1453, 2012
Coupling primary and stem cell–derived cardiomyocytes in an in vitro model of cardiac cell therapy
Y Aratyn-Schaus, FS Pasqualini, H Yuan, ML McCain, GJC Ye, ...
Journal of Cell Biology 212 (4), 389-397, 2016
Mitochondrial function in engineered cardiac tissues is regulated by extracellular matrix elasticity and tissue alignment
DM Lyra-Leite, AM Andres, AP Petersen, NR Ariyasinghe, N Cho, JA Lee, ...
American Journal of Physiology-Heart and Circulatory Physiology 313 (4 …, 2017
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