| Drug–target residence time: critical information for lead optimization H Lu, PJ Tonge Current opinion in chemical biology 14 (4), 467-474, 2010 | 499 | 2010 |
| The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase: adduct affinity and drug resistance R Rawat, A Whitty, PJ Tonge Proceedings of the National Academy of Sciences 100 (24), 13881-13886, 2003 | 465 | 2003 |
| Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis SL Kinnings, N Liu, N Buchmeier, PJ Tonge, L Xie, PE Bourne PLoS computational biology 5 (7), e1000423, 2009 | 399 | 2009 |
| Inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis, by triclosan and isoniazid SL Parikh, G Xiao, PJ Tonge Biochemistry 39 (26), 7645-7650, 2000 | 316 | 2000 |
| High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis TJ Sullivan, JJ Truglio, ME Boyne, P Novichenok, X Zhang, CF Stratton, ... ACS chemical biology 1 (1), 43-53, 2006 | 305 | 2006 |
| Inhibitors of FabI, an enzyme drug target in the bacterial fatty acid biosynthesis pathway H Lu, PJ Tonge Accounts of chemical research 41 (1), 11-20, 2008 | 300 | 2008 |
| Structural basis and mechanism of enoyl reductase inhibition by triclosan MJ Stewart, S Parikh, G Xiao, PJ Tonge, C Kisker Journal of molecular biology 290 (4), 859-865, 1999 | 286 | 1999 |
| A machine learning-based method to improve docking scoring functions and its application to drug repurposing SL Kinnings, N Liu, PJ Tonge, RM Jackson, L Xie, PE Bourne Journal of chemical information and modeling 51 (2), 408-419, 2011 | 248 | 2011 |
| Drug–target kinetics in drug discovery PJ Tonge ACS chemical neuroscience 9 (1), 29-39, 2018 | 245 | 2018 |
| Observation of excited-state proton transfer in green fluorescent protein using ultrafast vibrational spectroscopy D Stoner-Ma, AA Jaye, P Matousek, M Towrie, SR Meech, PJ Tonge Journal of the American Chemical Society 127 (9), 2864-2865, 2005 | 228 | 2005 |
| A slow, tight binding inhibitor of InhA, the enoyl-acyl carrier protein reductase from Mycobacterium tuberculosis SR Luckner, N Liu, CW Am Ende, PJ Tonge, C Kisker Journal of Biological Chemistry 285 (19), 14330-14337, 2010 | 226 | 2010 |
| Probing the ground state structure of the green fluorescent protein chromophore using Raman spectroscopy AF Bell, X He, RM Wachter, PJ Tonge Biochemistry 39 (15), 4423-4431, 2000 | 215 | 2000 |
| Roles of tyrosine 158 and lysine 165 in the catalytic mechanism of InhA, the enoyl-ACP reductase from Mycobacterium tuberculosis S Parikh, DP Moynihan, G Xiao, PJ Tonge Biochemistry 38 (41), 13623-13634, 1999 | 206 | 1999 |
| Novel Trisubstituted Benzimidazoles, Targeting Mtb FtsZ, as a New Class of Antitubercular Agents K Kumar, D Awasthi, SY Lee, I Zanardi, B Ruzsicska, S Knudson, ... Journal of medicinal chemistry 54 (1), 374-381, 2011 | 201 | 2011 |
| Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli D Tasdemir, B Topaloglu, R Perozzo, R Brun, R O’Neill, NM Carballeira, ... Bioorganic & medicinal chemistry 15 (21), 6834-6845, 2007 | 180 | 2007 |
| Translating slow-binding inhibition kinetics into cellular and in vivo effects GK Walkup, Z You, PL Ross, EKH Allen, F Daryaee, MR Hale, J O'donnell, ... Nature chemical biology 11 (6), 416-423, 2015 | 173 | 2015 |
| Inhibition of the bacterial enoyl reductase FabI by triclosan: A structure− reactivity analysis of FabI inhibition by triclosan analogues S Sivaraman, TJ Sullivan, F Johnson, P Novichenok, G Cui, C Simmerling, ... Journal of medicinal chemistry 47 (3), 509-518, 2004 | 161 | 2004 |
| Structure−Activity Studies of the Inhibition of FabI, the Enoyl Reductase from Escherichia coli, by Triclosan: Kinetic Analysis of Mutant FabIs S Sivaraman, J Zwahlen, AF Bell, L Hedstrom, PJ Tonge Biochemistry 42 (15), 4406-4413, 2003 | 143 | 2003 |
| Ultrafast structural dynamics in BLUF domains: transient infrared spectroscopy of AppA and its mutants AL Stelling, KL Ronayne, J Nappa, PJ Tonge, SR Meech Journal of the American Chemical Society 129 (50), 15556-15564, 2007 | 139 | 2007 |
| Targeting FtsZ for antituberculosis drug discovery: noncytotoxic taxanes as novel antituberculosis agents Q Huang, F Kirikae, T Kirikae, A Pepe, A Amin, L Respicio, RA Slayden, ... Journal of medicinal chemistry 49 (2), 463-466, 2006 | 139 | 2006 |
