| Next generation drying technologies for pharmaceutical applications RH Walters, B Bhatnagar, S Tchessalov, KI Izutsu, K Tsumoto, S Ohtake Journal of pharmaceutical sciences 103 (9), 2673-2695, 2014 | 239 | 2014 |
| Decreased protein-stabilizing effects of cryoprotectants due to crystallization K Izutsu, S Yoshioka, T Terao Pharmaceutical research 10, 1232-1237, 1993 | 226 | 1993 |
| Effect of mannitol crystallinity on the stabilization of enzymes during freeze-drying K IzUTsU, S YOSHIOKA, T TERAO Chemical and pharmaceutical bulletin 42 (1), 5-8, 1994 | 207 | 1994 |
| Freezing-and drying-induced perturbations of protein structure and mechanisms of protein protection by stabilizing additives JF Carpenter, K Izutsu, TW Randolph Freeze-drying/lyophilization of pharmaceutical and biological products, 181-211, 2016 | 154* | 2016 |
| Maintenance of quaternary structure in the frozen state stabilizes lactate dehydrogenase during freeze–drying TJ Anchordoquy, KI Izutsu, TW Randolph, JF Carpenter Archives of biochemistry and biophysics 390 (1), 35-41, 2001 | 149 | 2001 |
| Excipient crystallinity and its protein-structure-stabilizing effect during freeze-drying K Izutsu, S Kojima Journal of pharmacy and pharmacology 54 (8), 1033-1039, 2002 | 130 | 2002 |
| The effects of additives on the stability of freeze-dried β-galactosidase stored at elevated temperature I Ken-ichi, Y Sumie, T Yasushi International journal of pharmaceutics 71 (1-2), 137-146, 1991 | 106 | 1991 |
| Effects of sugars and polymers on crystallization of poly (ethylene glycol) in frozen solutions: phase separation between incompatible polymers K Izutsu, S Yoshioka, S Kojima, TW Randolph, JF Carpenter Pharmaceutical research 13, 1393-1400, 1996 | 98 | 1996 |
| Physical stability and protein stability of freeze-dried cakes during storage at elevated temperatures K Izutsu, S Yoshioka, S Kojima Pharmaceutical research 11, 995-999, 1994 | 93 | 1994 |
| Freeze-concentration separates proteins and polymer excipients into different amorphous phases K Izutsu, S Kojima Pharmaceutical research 17, 1316-1322, 2000 | 91 | 2000 |
| Freeze-drying of proteins with glass-forming oligosaccharide-derived sugar alcohols S Kadoya, K Fujii, K Izutsu, E Yonemochi, K Terada, C Yomota, ... International journal of pharmaceutics 389 (1-2), 107-113, 2010 | 86 | 2010 |
| Effect of counterions on the physical properties of l-arginine in frozen solutions and freeze-dried solids KI Izutsu, Y Fujimaki, A Kuwabara, N Aoyagi International journal of pharmaceutics 301 (1-2), 161-169, 2005 | 86 | 2005 |
| Increased stabilizing effects of amphiphilic excipients on freeze-drying of lactate dehydrogenase (LDH) by dispersion into sugar matrices K Izutsu, S Yoshioka, S Kojima Pharmaceutical research 12, 838-843, 1995 | 84 | 1995 |
| Near-infrared analysis of protein secondary structure in aqueous solutions and freeze-dried solids K Izutsu, Y Fujimaki, A Kuwabara, Y Hiyama, C Yomota, N Aoyagi Journal of pharmaceutical sciences 95 (4), 781-789, 2006 | 79 | 2006 |
| Characterization and quality control of pharmaceutical cocrystals K Izutsu, T Koide, N Takata, Y Ikeda, M Ono, M Inoue, T Fukami, ... Chemical and Pharmaceutical Bulletin 64 (10), 1421-1430, 2016 | 76 | 2016 |
| Applications of freezing and freeze-drying in pharmaceutical formulations K Izutsu Survival Strategies in Extreme Cold and Desiccation: Adaptation Mechanisms …, 2018 | 73 | 2018 |
| Stabilizing effect of amphiphilic excipients on the freeze‐thawing and freeze‐drying of lactate dehydrogenase K Izutsu, S Yoshioka, T Terao Biotechnology and bioengineering 43 (11), 1102-1107, 1994 | 73 | 1994 |
| Freeze-drying of proteins in glass solids formed by basic amino acids and dicarboxylic acids K Izutsu, S Kadoya, C Yomota, T Kawanishi, E Yonemochi, K Terada Chemical and Pharmaceutical Bulletin 57 (1), 43-48, 2009 | 71 | 2009 |
| Stabilization of β-galactosidase by amphiphilic additives during freeze-drying I Ken-ichi, Y Sumie, T Tadao International journal of pharmaceutics 90 (3), 187-194, 1993 | 61 | 1993 |
| Inactivation kinetics of enzyme pharmaceuticals in aqueous solution S Yoshioka, K Izutsu, Y Aso, Y Takeda Pharmaceutical research 8, 480-484, 1991 | 58 | 1991 |
Yukihiro GODADirector general, National Institute of Health Sciences, JapanVerified email at nihs.go.jp
