Eneda Toska, PhD
Eneda Toska, PhD
Johns Hopkins University School of Medicine
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PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor–positive breast cancer
A Bosch, Z Li, A Bergamaschi, H Ellis, E Toska, A Prat, JJ Tao, DE Spratt, ...
Science translational medicine 7 (283), 283ra51-283ra51, 2015
PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D
E Toska, HU Osmanbeyoglu, P Castel, C Chan, RC Hendrickson, ...
Science 355 (6331), 1324-1330, 2017
PDK1-SGK1 signaling sustains AKT-independent mTORC1 activation and confers resistance to PI3Kα inhibition
P Castel, H Ellis, R Bago, E Toska, P Razavi, FJ Carmona, S Kannan, ...
Cancer cell 30 (2), 229-242, 2016
Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors
N Vasan, P Razavi, JL Johnson, H Shao, H Shah, A Antoine, E Ladewig, ...
Science 366 (6466), 714-723, 2019
Resistance to TRK inhibition mediated by convergent MAPK pathway activation
E Cocco, AM Schram, A Kulick, S Misale, HH Won, R Yaeger, P Razavi, ...
Nature medicine 25 (9), 1422-1427, 2019
Resistance to TRK inhibition mediated by convergent MAPK pathway activation
E Cocco, AM Schram, A Kulick, S Misale, HH Won, R Yaeger, P Razavi, ...
Nature medicine 25 (9), 1422-1427, 2019
ARID1A determines luminal identity and therapeutic response in estrogen-receptor-positive breast cancer
G Xu, S Chhangawala, E Cocco, P Razavi, Y Cai, JE Otto, L Ferrando, ...
Nature genetics 52 (2), 198-207, 2020
Mechanisms of transcriptional regulation by WT1 (Wilms’ tumour 1)
E Toska, SGE Roberts
Biochemical Journal 461 (1), 15-32, 2014
Overview of the relevance of PI3K pathway in HR-positive breast cancer
N Vasan, E Toska, M Scaltriti
Annals of oncology 30, x3-x11, 2019
Selective inhibition of HDAC3 targets synthetic vulnerabilities and activates immune surveillance in lymphoma
P Mondello, S Tadros, M Teater, L Fontan, AY Chang, N Jain, H Yang, ...
Cancer discovery 10 (3), 440-459, 2020
Repression of transcription by WT1-BASP1 requires the myristoylation of BASP1 and the PIP2-dependent recruitment of histone deacetylase
E Toska, HA Campbell, J Shandilya, SJ Goodfellow, P Shore, KF Medler, ...
Cell reports 2 (3), 462-469, 2012
The present and future of PI3K inhibitors for cancer therapy
P Castel, E Toska, JA Engelman, M Scaltriti
Nature cancer 2 (6), 587-597, 2021
Neratinib is effective in breast tumors bearing both amplification and mutation of ERBB2 (HER2)
E Cocco, F Javier Carmona, P Razavi, HH Won, Y Cai, V Rossi, C Chan, ...
Science signaling 11 (551), eaat9773, 2018
FOXA1 mutations reveal distinct chromatin profiles and influence therapeutic response in breast cancer
A Arruabarrena-Aristorena, JLV Maag, S Kittane, Y Cai, WR Karthaus, ...
Cancer cell 38 (4), 534-550. e9, 2020
PI3K inhibition activates SGK1 via a feedback loop to promote chromatin-based regulation of ER-dependent gene expression
E Toska, P Castel, S Chhangawala, A Arruabarrena-Aristorena, C Chan, ...
Cell reports 27 (1), 294-306. e5, 2019
Presenilin influences glycogen synthase kinase-3 β (GSK-3β) for kinesin-1 and dynein function during axonal transport
K Dolma, GJ Iacobucci, K Hong Zheng, J Shandilya, E Toska, JA White, ...
Human molecular genetics 23 (5), 1121-1133, 2014
Panobinostat acts synergistically with ibrutinib in diffuse large B cell lymphoma cells with MyD88 L265P mutations
P Mondello, EJ Brea, E De Stanchina, E Toska, AY Chang, M Fennell, ...
JCI insight 2 (6), 2017
WT1 and its transcriptional cofactor BASP1 redirect the differentiation pathway of an established blood cell line
SJ Goodfellow, MR Rebello, E Toska, LAH Zeef, SG Rudd, KF Medler, ...
Biochemical Journal 435 (1), 113-125, 2011
PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer
A Glaviano, ASC Foo, HY Lam, KCH Yap, W Jacot, RH Jones, H Eng, ...
Molecular cancer 22 (1), 138, 2023
TRK xDFG mutations trigger a sensitivity switch from type I to II kinase inhibitors
E Cocco, JE Lee, S Kannan, AM Schram, HH Won, S Shifman, A Kulick, ...
Cancer discovery 11 (1), 126-141, 2021
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