| Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma AP Patel, I Tirosh, JJ Trombetta, AK Shalek, SM Gillespie, H Wakimoto, ... Science 344 (6190), 1396-1401, 2014 | 4306 | 2014 |
| Patterns of somatic mutation in human cancer genomes C Greenman, P Stephens, R Smith, GL Dalgliesh, C Hunter, G Bignell, ... Nature 446 (7132), 153-158, 2007 | 3734 | 2007 |
| AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients TT Batchelor, AG Sorensen, E di Tomaso, WT Zhang, DG Duda, ... Cancer cell 11 (1), 83-95, 2007 | 2075 | 2007 |
| Mutations of mitotic checkpoint genes in human cancers DP Cahill, C Lengauer, J Yu, GJ Riggins, JKV Willson, SD Markowitz, ... Nature 392 (6673), 300-303, 1998 | 1948 | 1998 |
| An integrative model of cellular states, plasticity, and genetics for glioblastoma C Neftel, J Laffy, MG Filbin, T Hara, ME Shore, GJ Rahme, AR Richman, ... Cell 178 (4), 835-849. e21, 2019 | 1664 | 2019 |
| Mesenchymal differentiation mediated by NF-κB promotes radiation resistance in glioblastoma KPL Bhat, V Balasubramaniyan, B Vaillant, R Ezhilarasan, K Hummelink, ... Cancer cell 24 (3), 331-346, 2013 | 1082 | 2013 |
| Genetic instability and darwinian selection in tumours DP Cahill, KW Kinzler, B Vogelstein, C Lengauer Trends in Genetics 15 (12), M57-M60, 1999 | 1068 | 1999 |
| Genomic characterization of brain metastases reveals branched evolution and potential therapeutic targets PK Brastianos, SL Carter, S Santagata, DP Cahill, A Taylor-Weiner, ... Cancer discovery 5 (11), 1164-1177, 2015 | 994 | 2015 |
| Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma I Tirosh, AS Venteicher, C Hebert, LE Escalante, AP Patel, K Yizhak, ... Nature 539 (7628), 309-313, 2016 | 965 | 2016 |
| Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells ML Suvà, E Rheinbay, SM Gillespie, AP Patel, H Wakimoto, SD Rabkin, ... Cell 157 (3), 580-594, 2014 | 923 | 2014 |
| Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq AS Venteicher, I Tirosh, C Hebert, K Yizhak, C Neftel, MG Filbin, ... Science 355 (6332), eaai8478, 2017 | 841 | 2017 |
| Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma M Snuderl, L Fazlollahi, LP Le, M Nitta, BH Zhelyazkova, CJ Davidson, ... Cancer cell 20 (6), 810-817, 2011 | 782 | 2011 |
| Post-operative stereotactic radiosurgery versus observation for completely resected brain metastases: a single-centre, randomised, controlled, phase 3 trial A Mahajan, S Ahmed, MF McAleer, JS Weinberg, J Li, P Brown, S Settle, ... The lancet oncology 18 (8), 1040-1048, 2017 | 651 | 2017 |
| Mutations in CIC and FUBP1 contribute to human oligodendroglioma C Bettegowda, N Agrawal, Y Jiao, M Sausen, LD Wood, RH Hruban, ... Science 333 (6048), 1453-1455, 2011 | 606 | 2011 |
| A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy C Hunter, R Smith, DP Cahill, P Stephens, C Stevens, J Teague, ... Cancer research 66 (8), 3987-3991, 2006 | 494 | 2006 |
| Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment DP Cahill, KK Levine, RA Betensky, PJ Codd, CA Romany, LB Reavie, ... Clinical cancer research 13 (7), 2038-2045, 2007 | 487 | 2007 |
| Adaptive chromatin remodeling drives glioblastoma stem cell plasticity and drug tolerance BB Liau, C Sievers, LK Donohue, SM Gillespie, WA Flavahan, TE Miller, ... Cell stem cell 20 (2), 233-246. e7, 2017 | 464 | 2017 |
| MSH6 mutations arise in glioblastomas during temozolomide therapy and mediate temozolomide resistance S Yip, J Miao, DP Cahill, AJ Iafrate, K Aldape, CL Nutt, DN Louis Clinical cancer research 15 (14), 4622-4629, 2009 | 464 | 2009 |
| IDH1 mutant malignant astrocytomas are more amenable to surgical resection and have a survival benefit associated with maximal surgical resection J Beiko, D Suki, KR Hess, BD Fox, V Cheung, M Cabral, N Shonka, ... Neuro-oncology 16 (1), 81-91, 2014 | 458 | 2014 |
| Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate L Bunse, S Pusch, T Bunse, F Sahm, K Sanghvi, M Friedrich, D Alansary, ... Nature medicine 24 (8), 1192-1203, 2018 | 420 | 2018 |
Hiroaki WakimotoMassachusetts General Hospital, Harvard Medical SchoolDirección de correo verificada de mgh.harvard.edu
