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Sarah R. Hengel
Sarah R. Hengel
University of Pittsburgh, Hillman Cancer Center
Dirección de correo verificada de pitt.edu
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Año
RAD51 Gene Family Structure and Function
B Bonilla, SR Hengel, MKK Grundy, KA Bernstein
Annual review of genetics 54, 25-46, 2020
1442020
Small-molecule inhibitors targeting DNA repair and DNA repair deficiency in research and cancer therapy
SR Hengel, MA Spies, M Spies
Cell chemical biology 24 (9), 1101-1119, 2017
1432017
Small-molecule inhibitors identify the RAD52-ssDNA interaction as critical for recovery from replication stress and for survival of BRCA2 deficient cells
SR Hengel, E Malacaria, L Folly da Silva Constantino, FE Bain, A Diaz, ...
Elife 5, e14740, 2016
842016
Crystallographic and nuclear magnetic resonance evaluation of the impact of peptide binding to the second PDZ domain of protein tyrosine phosphatase 1E
J Zhang, PJ Sapienza, H Ke, A Chang, SR Hengel, H Wang, ...
Biochemistry 49 (43), 9280-9291, 2010
722010
Mismatch repair protein hMSH2–hMSH6 recognizes mismatches and forms sliding clamps within a D-loop recombination intermediate
M Honda, Y Okuno, SR Hengel, JV Martín-López, CP Cook, ...
Proceedings of the National Academy of Sciences 111 (3), E316-E325, 2014
452014
DSS1 interacts with and stimulates RAD52 to promote the repair of DSBs
B Stefanovie, SR Hengel, J Mlcouskova, J Prochazkova, M Spirek, ...
Nucleic acids research 48 (2), 694-708, 2020
312020
Distinct roles for conformational dynamics in protein-ligand interactions
X Liu, DC Speckhard, TR Shepherd, YJ Sun, SR Hengel, L Yu, CA Fowler, ...
Structure 24 (12), 2053-2066, 2016
302016
The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway
JC Rosenbaum, B Bonilla, SR Hengel, TM Mertz, BW Herken, ...
Nature communications 10 (1), 3515, 2019
292019
Small-molecule inhibitors identify the RAD52-ssDNA interaction as critical for recovery from replication stress and for survival of BRCA2 deficient cells
FE Bain, A Diaz, BG Koch, L Yu, M Wu, P Pichierri, MA Spies, M Spies
Elife 5, e14740, 2016
132016
Folly da Silva Constantino L, Bain FE, Diaz A, Koch BG, Yu L, Wu M, Pichierri P, Spies MA et al. Small-molecule inhibitors identify the RAD52-ssDNA interaction as critical for …
SR Hengel, E Malacaria
Elife 5, 2016
102016
Folly da Silva Constantino L, Bain FE, Diaz A, Koch BG, et al. Small-molecule inhibitors identify the RAD52-ssDNA interaction as critical for recovery from replication stress …
SR Hengel, E Malacaria
Elife 5, e14740, 2016
72016
Therapeutic disruption of RAD52–ssDNA complexation via novel drug-like inhibitors
DS Bhat, E Malacaria, LD Biagi, M Razzaghi, M Honda, KF Hobbs, ...
NAR cancer 5 (2), zcad018, 2023
52023
The Shu complex prevents mutagenesis and cytotoxicity of single-strand specific alkylation lesions
B Bonilla, AJ Brown, SR Hengel, KS Rapchak, D Mitchell, CA Pressimone, ...
Elife 10, e68080, 2021
42021
Unlicensed origin DNA melting by MCV and SV40 polyomavirus LT proteins is independent of ATP-dependent helicase activity
L Wan, S Toland, LR Robinson-McCarthy, N Lee, MA Schaich, SR Hengel, ...
Proceedings of the National Academy of Sciences 120 (30), e2308010120, 2023
32023
Analysis of NIH K99/R00 awards and the career progression of awardees
NC Woitowich, SR Hengel, C Solis, TP Vilgalys, J Babdor, DJ Tyrrell
Elife 12, RP88984, 2024
12024
The human Shu complex promotes RAD51 activity by modulating RPA dynamics on ssDNA.
SR Hengel, K Oppenheimer, C Smith, M Schaich, HL Rein, J Martino, ...
bioRxiv, 2024.02. 14.580393, 2024
2024
Analysis of NIH Biomedical Faculty K99 Awards, Transitions, and R00 Outcomes
NC Woitowich, SR Hengel, TP Vilgalys, J Babdor, DJ Tyrrell
bioRxiv, 2023.01. 26.525751, 2023
2023
SWSAP1-SWS1 Stimulates D-Loop Formation on RPA-Coated SsDNA
SR Hengel, KG Oppenheimer, K Bernstein
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS 63, 80-80, 2022
2022
Genetic Determinants of Disease Risk from Environmental DNA Damage.
S Hengel, C Smith, K Bernstein
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS 62, 45-45, 2021
2021
The BRCA2-interacting Protein, PDS5B, and SPIDR are Novel Shu Complex Components.
SR Hengel, J Martino, G Brunette, J Barroso-Gonzales, T Moiseeva, ...
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS 61, 77-77, 2020
2020
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