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Mercedes Lobera
Mercedes Lobera
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Year
Individual intestinal symbionts induce a distinct population of RORγ+ regulatory T cells
E Sefik, N Geva-Zatorsky, S Oh, L Konnikova, D Zemmour, AM McGuire, ...
Science 349 (6251), 993-997, 2015
8402015
Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages
JL Guerriero, A Sotayo, HE Ponichtera, JA Castrillon, AL Pourzia, ...
Nature 543 (7645), 428-432, 2017
4822017
Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group
M Lobera, KP Madauss, DT Pohlhaus, QG Wright, M Trocha, DR Schmidt, ...
Nature chemical biology 9 (5), 319-325, 2013
3642013
Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms
S Xiao, N Yosef, J Yang, Y Wang, L Zhou, C Zhu, C Wu, E Baloglu, ...
Immunity 40 (4), 477-489, 2014
3102014
Pharmacologic inhibition of RORγt regulates Th17 signature gene expression and suppresses cutaneous inflammation in vivo
J Skepner, R Ramesh, M Trocha, D Schmidt, E Baloglu, M Lobera, ...
The Journal of Immunology 192 (6), 2564-2575, 2014
1852014
An activated Th17-prone T cell subset involved in chronic graft-versus-host disease sensitive to pharmacological inhibition
E Forcade, K Paz, R Flynn, B Griesenauer, T Amet, W Li, L Liu, ...
JCI insight 2 (12), 2017
672017
Synthesis of 2, 3-dihydro-3-hydroxy-2-hydroxylalkylbenzofurans from epoxy aldehydes. One-step syntheses of brosimacutin G, vaginidiol, vaginol, smyrindiol, xanthoarnol, and …
Y Zou, M Lobera, BB Snider
The Journal of Organic Chemistry 70 (5), 1761-1770, 2005
552005
S1P receptor modulating compounds and use thereof
AK Saha, N Schutz, X Yu, D McCauley, M Lobera, Y Marantz, J Lin, ...
US Patent 7,855,193, 2010
452010
Improved syntheses of the naturally occurring glycosidase inhibitor salacinol
A Ghavami, KS Sadalapure, BD Johnston, M Lobera, BB Snider, BM Pinto
Synlett 2003 (09), 1259-1262, 2003
422003
Benzofuran Derivatives as Potent, Orally Active S1P1 Receptor Agonists: A Preclinical Lead Molecule for MS
AK Saha, X Yu, J Lin, M Lobera, A Sharadendu, S Chereku, N Schutz, ...
ACS Medicinal Chemistry Letters 2 (2), 97-101, 2011
392011
S1P receptor modulating compounds and use thereof
R Burli, VJ Cee, J Golden, BA Lanman, S Neira, A Saha, N Schutz, X Yu, ...
US Patent 7,919,519, 2011
302011
Compounds and methods
E Baloglu, S Ghosh, M Lobera, D Schmidt
US Patent 8,901,156, 2014
29*2014
From RORγt agonist to two types of RORγt inverse agonists
Y Wang, W Cai, T Tang, Q Liu, T Yang, L Yang, Y Ma, G Zhang, Y Huang, ...
ACS Medicinal Chemistry Letters 9 (2), 120-124, 2018
282018
Substituted arylamine compounds and methods of treatment
O Becker, R Melendez, Y Marantz, A Sharadendu, M Fichman, M Lobera, ...
US Patent 7,968,538, 2011
262011
Discovery of a Potent, S1P3-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P1)
BA Lanman, VJ Cee, SR Cheruku, M Frohn, J Golden, J Lin, M Lobera, ...
ACS Medicinal Chemistry Letters 2 (2), 102-106, 2011
262011
Synthesis of the tetracyclic core of the bisabosquals
BB Snider, M Lobera
Tetrahedron letters 45 (26), 5015-5018, 2004
242004
In vivo regulation of gene expression and T helper type 17 differentiation by RORγt inverse agonists
J Skepner, M Trocha, R Ramesh, XA Qu, D Schmidt, E Baloglu, M Lobera, ...
Immunology 145 (3), 347-356, 2015
222015
Synthesis of the alkenyl-substituted tetracyclic core of the bisabosquals
J Zhou, M Lobera, BJ Neubert-Langille, BB Snider
Tetrahedron 63 (40), 10018-10024, 2007
202007
Thienopyridinone compounds and methods of treatment
DS Dhanoa, O Becker, S Noiman, L Wu, M Lobera, P Mohanty, Y Marantz, ...
US Patent 7,407,966, 2008
162008
TMP778, a selective inhibitor of RORγt, suppresses experimental autoimmune uveitis development, but affects both Th17 and Th1 cell populations
C Lyu, SJ Bing, WS Wandu, B Xu, G Shi, SJ Hinshaw, M Lobera, ...
European journal of immunology 48 (11), 1810-1816, 2018
152018
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