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Edward W. Tate
Edward W. Tate
Imperial College London & Francis Crick Institute
Dirección de correo verificada de imperial.ac.uk - Página principal
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FSP1 is a glutathione-independent ferroptosis suppressor
S Doll, FP Freitas, R Shah, M Aldrovandi, MC da Silva, I Ingold, AG Grocin, ...
Nature 575, 693-698, 2019
18452019
Protein myristoylation in health and disease
MH Wright, WP Heal, DJ Mann, EW Tate
Journal of chemical biology 3, 19-35, 2010
2872010
Global profiling of co- and post-translationally N-myristoylated proteomes in human cells
E Thinon, RA Serwa, M Broncel, JA Brannigan, U Brassat, MH Wright, ...
Nature communications 5 (1), 4919, 2014
2422014
Activity-based probes: discovering new biology and new drug targets
WP Heal, THT Dang, EW Tate
Chemical Society Reviews 40 (1), 246-257, 2011
2132011
Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach
MH Wright, B Clough, MD Rackham, K Rangachari, JA Brannigan, ...
Nature chemistry 6 (2), 112-121, 2014
2122014
Antibody–PROTAC conjugates enable HER2-dependent targeted protein degradation of BRD4
M Maneiro, N Forte, MM Shchepinova, CS Kounde, V Chudasama, ...
ACS chemical biology 15 (6), 1306-1312, 2020
1862020
Chemical and biomimetic total syntheses of natural and engineered MCoTI cyclotides
P Thongyoo, N Roqué-Rosell, RJ Leatherbarrow, EW Tate
Organic & biomolecular chemistry 6 (8), 1462-1470, 2008
1712008
N-Myristoyl transferase-mediated protein labelling in vivo
WP Heal, SR Wickramasinghe, RJ Leatherbarrow, EW Tate
Organic & biomolecular chemistry 6 (13), 2308-2315, 2008
1692008
Potent inhibitors of β-tryptase and human leukocyte elastase based on the MCoTI-II scaffold
P Thongyoo, C Bonomelli, RJ Leatherbarrow, EW Tate
Journal of medicinal chemistry 52 (20), 6197-6200, 2009
1562009
Dynamic protein acylation: new substrates, mechanisms, and drug targets
T Lanyon-Hogg, M Faronato, RA Serwa, EW Tate
Trends in biochemical sciences 42 (7), 566-581, 2017
1282017
Genome-wide functional analysis of Plasmodium protein phosphatases reveals key regulators of parasite development and differentiation
DS Guttery, B Poulin, A Ramaprasad, RJ Wall, DJP Ferguson, D Brady, ...
Cell host & microbe 16 (1), 128-140, 2014
1222014
N-myristoyltransferase from Leishmania donovani: structural and functional characterisation of a potential drug target for visceral leishmaniasis
JA Brannigan, BA Smith, Z Yu, AM Brzozowski, MR Hodgkinson, A Maroof, ...
Journal of molecular biology 396 (4), 985-999, 2010
1172010
Multifunctional protein labeling via enzymatic N-terminal tagging and elaboration by click chemistry
WP Heal, MH Wright, E Thinon, EW Tate
Nature protocols 7 (1), 105-117, 2012
1142012
Global profiling of protein lipidation using chemical proteomic technologies
EW Tate, KA Kalesh, T Lanyon-Hogg, EM Storck, E Thinon
Current opinion in chemical biology 24, 48-57, 2015
1112015
Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus
A Mousnier, AS Bell, DP Swieboda, J Morales-Sanfrutos, I Pérez-Dorado, ...
Nature chemistry 10 (6), 599-606, 2018
1042018
Bioorthogonal chemical tagging of protein cholesterylation in living cells
WP Heal, B Jovanovic, S Bessin, MH Wright, AI Magee, EW Tate
Chemical communications 47 (14), 4081-4083, 2011
992011
Selective Inhibitors of Protozoan Protein N-myristoyltransferases as Starting Points for Tropical Disease Medicinal Chemistry Programs
AS Bell, JE Mills, GP Williams, JA Brannigan, AJ Wilkinson, T Parkinson, ...
PLoS neglected tropical diseases 6 (4), e1625, 2012
972012
Dual chemical probes enable quantitative system-wide analysis of protein prenylation and prenylation dynamics
EM Storck, J Morales-Sanfrutos, RA Serwa, N Panyain, T Lanyon-Hogg, ...
Nature Chemistry 11 (6), 552-561, 2019
942019
Multifunctional reagents for quantitative proteome‐wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development
M Broncel, RA Serwa, P Ciepla, E Krause, MJ Dallman, AI Magee, ...
Angewandte Chemie International Edition 54 (20), 5948-5951, 2015
912015
Global analysis of protein N-myristoylation and exploration of N-myristoyltransferase as a drug target in the neglected human pathogen Leishmania donovani
MH Wright, D Paape, EM Storck, RA Serwa, DF Smith, EW Tate
Chemistry & biology 22 (3), 342-354, 2015
892015
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Artículos 1–20